Abstract
Background/Objective
Recent studies suggested oxidized low density lipoprotein (ox-LDL) is involved in oxidative stress and inflammation, which are the key characteristics of chronic obstructive pulmonary disease (COPD). This study aimed to investigate the serum levels of ox-LDL in COPD patients and their correlations with lung function, systematic inflammation and oxidative stress.
Method
48 COPD patients and 32 healthy controls were recruited. Serum ox-LDL and C-reactive protein (CRP) levels were analyzed by enzyme-linked immunosorbent assay, oxidative stress was analyzed by measurement of Reactive Oxygen Species (ROS) with a colorimetric kit.
Results
The clinical summary of included subjects was listed in Table 1.
The levels of serum ox-LDL were significantly elevated in COPD patients when compared to controls (18.62±7.56 mU/L vs. 12.57±5.90 mU/L, p < 0.05). The levels of serum CRP and ROS were significantly higher in COPD patients. Regression correlation analysis showed that serum ox-LDL levels were inversely correlated with lung function (r=-0.347, p=0.016), while positively with serum CRP and ROS levels in COPD patients (For CRP, r=0.365, p=0.011; for ROS, r=0.346, p=0.016).
Conclusion
Serum ox-LDL levels are increased in COPD patients, and are associated with lung function, systematic inflammation and oxidative stress in COPD.
- © 2013 ERS