Abstract
Background: There is evidence that the acid-fast bacilli clearance from sputum is delayed in tuberculosis (TB) patient with diabetes mellitus (DM). The aim of study was to compare the time of sputum smear conversion and the clearance of mycobacteria from sputum during the treatment of multi-drug resistant TB with DM and without DM patients.
Methods: During 2003- 2011, 25 adult patients with MDR-TB and DM and 25 age- and sex-matched patients with MDR-TB without DM were included in the study. All patients received standardized MDR-TB treatment consisted of ofloxacin, cycloserine, amikacin, prothionamide. Time of sputum smear conversion was evaluated in both groups. The clearance of bacilli from sputum smear was compared every 15 days by using repeated measure analysis.
Results: The mean time of sputum smear conversion was 2.82±1.79 months in patients with MDR-TB and DM, and 3.06±1.76 months in patients with MDR-TB only (P=0.63). Repeated measure analysis revealed that the clearance of acid-fast bacilli from sputum in diabetic patients over time was significantly higher than non-DM patients (P=0.009)
.
Conclusion: The time of mycobacterial clearance of sputum smear in diabetic MDR-TB patients was higher than MDR-TB only.
- © 2014 ERS