Abstract
Objective: To study the differences in symptoms, cardiovascular comorbidity, sleep respiratory parameters and of biochemical plasma measures between patients with COPD and obstructive sleep apnoea syndrome (OSAS) (overlap syndrome) and patients with only OSAS.
Material and Methods: 92 patients were included in the study (overlap syndrome (n=43) and OSAHS (n=49) ).
Clinical characteristics, comorbidities. sleep study, haemoglobin, haematocrit, glucose, lipid profile, uric acid and C-reactive protein were recorded.
Results: By comparing the overlap group with the OSAHS group, we found the following significant differences:
1) Clinical: age, neck circumference and SpO2.
2) The overlap group had more cardiovascular risk factors, exsmokers and history of ischaemic heart disease. The OSAS-group had more dyslipidemia.
3) The overlap group had a lower mean SpO2 and higher CT90. OSAS group had longer apnoeic events and greater point drops in the desaturations.
4) The LDL values were higher in the OSAS group, and the CRP values were higher in the overlap group.
A correlation analysis of the patients in the overlap group there was a significant positive association between FEV1 and the mean SpO2 and the minimum SpO2 in the sleep study, and negative association with the duration of the apnoeic events age.
Conclusions:
1) The patients with overlap syndrome have more cardiovascular comorbidity and greater systemic inflammation than those with only OSAS.
2) The patients with OSAH had longer apnoeic events and larger point drops in desaturation than the overlap patients.
3) We found a positive association between FEV1 and the nocturnal oximetry values and a negative association with the duration of the apnoeic events.
- Copyright ©ERS 2015