Abstract
Objective: To compare the yield from gastric lavage (GL) and Broncho alveolar lavage (BAL) samples in adult patient suspected case of TB but not producing sputum.
Methods: Total 80 consecutive adults with suspected case of tuberculosis who were not producing sputum were recruited. 72 patients prospectively subjected to one gastric lavage and followed by Broncho-alveolar lavage on the same morning. The collected samples were subjected to GeneXpert MTB/RIF Assay.
Results: Sample of 72 patients were collected. Mean age was 38.6±18.3. 41(56.9%) were male and 31(43.1%) were female. History of TB contact was present in 34.8%. Total 37 (51.4%) patients had GeneXpert MTB/RIF positive on BAL and/or GL samples. The GeneXpert MTB/RIF of BAL fluid was positive on 35(48.6%), which was not significantly greater than that for specimens from GL i.e. 28 (38.9%) (p> 0.05). In 26 (36.1%) cases GeneXpert MTB/RIF was positive both in both BAL and GA samples.
Positive n(%) | Negative n(%) | p value | |
BAL | 35(48.6%) | 37(51.4%) | >0.05 |
GL | 28(38.9%) | 44(61.1%) | |
Total Positive Cases (BAL and/or GL) | 37(51.4%) | 35(48.6%) |
Conclusion: This study showed that the yield of GeneXpert MTB/RIF in GL was equally effective to BAL to detect Mycobacterium Tuberculosis complex. Patients who can't produce sputum, GL can be a good alternative to BAL to detect Mycobacterium Tuberculosis complex in resource poor areas and patient who doesn't tolerate Bronchoscopy.
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