Abstract
Background: For the present moment changes occurring in RM, during COPD, have been studied insufficiently.
Aim and objectives: to investigate the RM status and compare them with histological data of bioptic muscular material.
Material and methods: The peak histogram of the internal oblique abdominal muscle (intOAM) was detected by ultrasonic scanner. We obtained the indices: homogeneity (H), structural density (SD) and echogenicity (E). Histological research of bioptic material of intOAM has been carried out.
Research was made in 13 pts: 1st group: 8 at the 1st COPD stage; mean age 56 yrs; BMI 24kg/m2; 2nd group: 5 at the 2nd COPD stage, mean age 59 yrs; BMI 24kg/m2. Control group was formed of 10 healthy subjects compared according to age-, sex- and BMI.
Results: Contractions, small sites of a fragmentation, stratification of myofibrils and proliferation of fibroblasts were observed at the 1st and 2nd COPD stage. We revealed scleroses of single muscular fibril and foci of sclerosis in intramuscular regions. The median H in the 1st and 2nd groups was 21 and 18 units respectively. Increasing severity of COPD was associated with enhancing of contractions and stratification of myofibrils. Thus, we detected the significant correlations between COPD severity and contractions (r=0,72) and with stratification of myofibrils (r=0,66). Indices H and SD were lower in pts with more scleroses manifestations (r= - 0,42 and r= - 0,59). Whereas index E was higher in these patients (r=0,59). The pack/years significantly correlated with intensity of proliferation of fibroblasts (r=0,56).
Conclusions: Indices H, E, SD reflect the pathological processes occurring in RM in COPD patients.
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