Abstract
Many studies demonstrate huge prevalence of arterial hypertension (AH) in patients with obstructive sleep apnea (OSA).
The purpose of this study was to identify blood pressure parameters in patients with OSA and its combination with COPD (overlap syndrome (OS)).
Material and methods: 50 patients with excessive daytime sleepiness and OSA (verified by polysomnography), age 47,12±2,16 years, 54 patients with OS (Post BD FEV1/FVC (58,57±2,03)%, FEV1 (66,71±3,14)%), age 57,85±1,36 years and 10 healthy subjects(age 54,1±4,31years). All patients were not previously aware of their cardiovascular pathology. All patients underwent ambulatory blood pressure monitoring (ABPM).AH diagnosed in patients with office systolic blood pressure (SBP)≥140 and diastolic blood pressure (DBP)≥90 mmHg.
Results.
Office SBP and DBP in OSA group were 12 and 10% higher vs healthy subjects (p<0,0001); diurnal SBP (SBP24) and DBP24 were also 8 and 11% higher (p<0,005).
Office SBP and DBP in OS group were 17 and 13% higher vs healthy subjects (p<0,0001); SBP24 and DBP24 -- 15% higher (p<0,0001).
SBP24 in OS group was 7% higher vs OSA group (p<0,005).
AH was diagnosed in 38% patients with OSA and 65% patients with OS.
Conclusion. COPD in combination with OSA has more negative effects on blood pressure then isolated OSA. Prevalence of AH in OS group was 27% higher than in patients with OSA.
- © 2014 ERS