Abstract
Introduction: Many investigators have tried to identify a simple blood test or predicting rules that can help physicians to make more rational decisions to identify patients who are at risk for adverse outcomes or death.
Aim: The aim of this study was to investigate the prognostic value of plasma D-dimer, CRP and some other biomarkers levels in patients with CAP.
Materials and Methods: In this study were enrolled 72 patients admitted on Sept - Dec 2011 with clinical and radiological evidence of CAP. Within 24 hours after admission and on the 4-th day blood samples were taken for analysis. CURB-65 and PSI severity scores were calculated at admission. Statistical analysis is made with SPSS 19.0.
Results: Mean age 62.7±16.6 years(range 25-92).Mean D-dimer on the first day resulted 2621ng/ml(range 296-9000),on the 4-th day 2585 ng/ml (range120-9000). Mean CRP on the first day resulted 198 mg/l(range 0.76 - 743),on the 4-th day 72 mg/l(range 0.10 - 316). On admission mean value of fibrinogen was 811mg/dl(range 279-1780); APTT– 37.39 sec (range 17- 100); leukocyte –15363 (range 1900- 47200); ESR-28 mm/hr(range 2-68);fever – 37.8ºC (range 36.4- 41). Mean hospitalization 9.65 days (range 0- 35).Mean values of D-dimer and CRP resulted in correlation with complications events. Even though mean values of D-dimer and CRP are higher, no significant correlations resulted between them and CURB-65 and PSI score. Significantly mean values of D-dimer and CRP are higher on groups of patients with complicated CAP(p < 0.004).
Conclusion: D-dimer and CRP level cannot replace CURB-65 or PSI scoring for assessment in CAP patients, but are useful to predict clinical outcome, especially complications in pacients with CAP.
- © 2012 ERS