Abstract
Introduction: The use of broncho alveolar lavage (BAL) and surfactant therapy has been tested in humans and in animal models getting promising results as well as Bag-squezing maneuver has shown good results in adults.
Aims: To evaluate the effects of the combination of Bag Squeezing maneuver with broncho-alveolar surfactant in an experimental model of Meconium Aspiration Syndrome in newborn pigs.
Methodology: were used in the study newborn pigs (n = 15), ventilated with fixed parameters. After instillation of human meconium 4ml/Kg diluted to 20%, the pigs were randomized into three groups: CONTROL-SAM model subjected only aspiration (n = 5), Grupo BAL-SAM model treated only with surfactant BAL (n = 5), and Grupo BAL + BAG-SAM model treated with BAL with surfactant associated with Bag Squeezing maneuver (n = 5). For the LBA was used 15ml/kg of Curosurf™ diluted in NaCl (5mg/ml). Blood gases, vital signs and behavior of mechanical ventilation were analyzed throughout the study.
Results: The that group received a BAL + BAG improved blood gas, reducted of airway resistance (p = 0, 004) and compliance lung (p = 0.003) better than the other groups with a significant increase in the amount of meconium removed (p = 0.046) with the bag-squeezing maneuver.
Conclusion: The association of Bag-squeezing maneuver can bring benefits to gasometric parameters mechanical ventilation and increase the removal of meconium.
- © 2012 ERS