Abstract
Asthma is a common chronic respiratory disease resulting from interactions between multiple genes and environmental factors. Glucocorticosteroids are currently the most effective anti-inflammatory medications for the treatment of asthma. Studies have demonstrated their efficacy in reducing asthma symptoms, controlling airway inflammation and improving quality of life. The aim of the study was to investigate the association SNPs in glucocorticoid receptor (GR (rs41423247)) and corticotropin-releasing hormone receptor 1 (CRHR1 (rs242939, rs1876828)) genes with asthma. A total of 200 unrelated asthma patients and 101 non-atopic individuals from the Volga-Ural region of Russia were recruited.
We have determined an association SNP rs41423247 of the GR gene with asthma.The frequency of allele rs41423247*C was increased in asthmatics (63,25%) compared to controls (52,48%, p=0,01; OR=1,56 (95%CI 1,11-2,20)). In control group, the frequency of genotype rs41423247*G/G was significantly higher (25,74%) than in asthma group (15,5%, 0,03; OR=0,53 (95%CI 0,29-0,95).
We found significant association of allele rs41423247*C with decrease FEV1 and VC in patients. Allele rs41423247*C was also associated with clinical response to inhaled corticosteroids treatment (p=0,04; OR=1,50 (95%CI 1,01-22,22)) and asthma severity (p=0,03; OR=1,78; 95% CI 1,05-3,01).
In summary, our results suggest an important role for SNP rs41423247 of GR gene in the development of asthma in the Volga-Ural region of Russia. Supported by the Russian Foundation for Basic Research, grant RFBR No. 13-04-01397 A.
- © 2014 ERS