Abstract
Aim:The objective of the study was to evaluate the intensive care unit (ICU) and long term mortality in severe sepsis patients (SSP) with/without thrombocytopenia in the 5th day of ICU admission.
Methods: The retrospective observational cohort study was done in teaching hospital and SSP were included if stayed more than 4 days in the ICU. Patients were grouped into two according to platelet count below (Group1) and above (Group2) 150000. Patients' characteristics, sepsis findings, ICU data were recorded. Groups were compared according to recorded data. Logistic regression analysis was done for ICU mortality, Kaplan Meier test was used to evaluate 12 months survival.
Results: During period, 1003 patients admitted to the ICU, 573 SSP and 307 patients were included to the study. Group 1 (n=67) and Group 2 (n=240) had similar patients' characteristics and sepsis findings. Groups had similar ICU and hospital stay; mortality was higher in Group 1 than 2 (40.3% vs. 1.5%, p<0.001 respectively). Fifth day thrombocytopenia, septic shock, male gender, low albumin levels were found as risk factors of ICU mortality and Odds ratio, 95% confidence interval [ ], p values respectively 3.03,[1.15-7.45], p<0.025, 4.97,[1.79-13.86], p<0.002, 3.61,[1.27-10.23],p<0.001 and 0.19,[0.07-0.52],p<0.001. Follow-up in one year, 124 out of 238 (52.1%) patients were died and 50% of the deaths occurred in the first 2 months.
Conclusion: Higher rate of septic shock, mortality were seen in SSP with thrombocytopenia in the ICU. Close follow-up is recommended for thrombocytopenic sepsis patients after ICU discharge due to high mortality in two months.
- © 2014 ERS