Abstract
Urinary albumin excretion is associated with endothelial dysfunction. Untreated OSA is risk factor for endothelial injury (oxidative stress, thrombosis, inflammation) and finally cardiovascular complications. The aim of this study was to estimate a frequency of albuminuria and association with concomitant diseases in OSA pts. We studied 159 subjects with moderate and severe OSA - AHI= 41.5±20.7, BMI=34.4±6.4 kg/m2, age - 57±10.6 years, mean SaO2=90.7±6.9% (114 males -71.7% and 45 females -28.3%). Albuminuria (> 20mg/L) was found in 33 subjects (20.8% - group 1). Comparison of groups with and without albuminuria (group 0) is shown in the table below.
Variable | Group 0 | Group 1 | p |
Age (years) | 57.2±10.4 | 56.3±11.4 | NS |
BMI (kg/m2) | 33.8±6.1 | 36.5±7.2 | NS |
AHI (n/h) | 40.7±19.5 | 44.5±24.8 | NS |
T90 (%) | 20.7±26.4 | 27.3±32.4 | NS |
Mean SaO2 (%) | 91.3±5.7 | 88.4±10 | NS |
Arterial hypertension (AH) (n/% of pts) | 88 (69.8%) | 25 (75.8%) | NS |
Coronary artery disease (CAD) (n/% of pts) | 22 (17.5%) | 9 (27.3%) | NS |
Heart failure (HF) (n/% of pts) | 6 (4.8%) | 6 (18.2%) | p=0.009 |
Atrial fibrillation (AF) (n/% of pts) | 8 (6.3%) | 3 (9.1%) | NS |
Stroke (n/% of pts) | 7 (5.6%) | 1 (3%) | NS |
Diabetes (n/% of pts) | 22 (17.5%) | 12 (36.4%) | p=0.02 |
Nephrolithiasis (n/% of pts) | 3 (2.4%) | 6 (18.2%) | p=0.003 |
Logistic regression analysis revealed that only nephrolithiasis (OR- 0.1; 95%CI – 0.01-0.7; p=0.02) was independent predictor of albuminuria after adjusting for AH, CAD, HF, AF, Diabetes, AHI > 30 vs ≤30, T90 >30 vs ≤ 30.
Conclusions: Albuminuria was found in 20% of OSA subjects. Main predictor of urinary albumin excretion was nephrolithiasis.
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