Abstract
Objective: To evaluate the age-specific mortality in a national TB cohort, and to estimate relative age-specific mortality compared with matched controls, in a retrospective case-control study.
Methods: Using Danish National Patient Registry, we retrospectively identified TB-patients between 1998-2010. They were matched to controls by age, gender, civil status and geography. Mortality data were obtained from Danish Civil Registration System. We calculated age-specific hazard ratio and cumulative survival function, adjusting for varying follow-up, distributing.
Results: 6713 cases and 28217 controls were followed for max. 12 (span: 0-12) years. Mortality was higher for cases than controls in all age groups, and significantly so for age groups above 20 years, peaking at a Hazard Ratio of 8.7 (95% CI: 5.53;16.69) in the 30-39 years age. Absolute difference in mortality increased with older age.
Age group | Cases, N | Mortality share, Cases | Controls, N | Mortality share, Controls | Hazard ratio | P-value |
0-9 years | 374 | 0.5 % | 1609 | 0.2 % | 2.84 | 0,2543 |
10-19 years | 459 | 0.7 % | 2116 | 0.2 % | 4.09 | 0.0844 |
20-29 years | 786 | 1.7 % | 3474 | 0.3 % | 7.51 | 0.0000 |
30-39 years | 1137 | 5.1 % | 4883 | 0.6 % | 8.70 | 0.0000 |
40-49 years | 1139 | 14.0 % | 4747 | 2.8 % | 5.85 | 0.0000 |
50-59 years | 944 | 27.6 % | 3813 | 6.1 % | 5.68 | 0.0000 |
60-69 years | 737 | 40.8 % | 3010 | 12.5 % | 4.34 | 0.0000 |
70-79 years | 723 | 56.0 % | 2911 | 30.0 % | 2.61 | 0.0000 |
80+ years | 414 | 74.6 % | 1654 | 55.6 % | 2.00 | 0.0000 |
Absolute mortality for cases and controls, and hazard ratio of mortality, adjusted for varying follow-up.
Conclusion: Cumulative mortality of TB-patients is significantly inferior to matched controls. While the difference in survival is substantial among elderly patients, a high relative risk of dying is particularly of concern among young and middle-aged adult TB patients.
- Copyright ©ERS 2015