Abstract
Aim of this study to evaluate associations between the adipokines (tumor necrosis factor-alpha (TNF-α) and its receptors, leptin, adiponectin), body composition and bone mineral density (BMD) in the patients with terminal stage of chronic respiratory failure.
Material and methods: 47 patients with end-stage of chronic respiratory failure (COPD, emphysema and cystic fibrosis) and 35 healthy subjects were estimated. Bone mineral density, wool body composition was measured by dual-energy X-ray absorptiometry (DEXA) at the lumbar spine (LS) and left femur neck (FN). We estimated respiratory function testing, serum levels TNF-α, TNFR-1, TNFR-2, leptin, adiponectin.
Results: We indentified a decreased BMD characterized by T-score <-1,0 in 43/47 patients, as measured on the FN or the lumbar spine (LS). There was negative association between TNF-α and BMD (r=-0,43, p=0,04). Parameters of body compositions and serum concentrations of leptin and adiponectin were significantly associated with FN hip and LS. Serum leptin levels was significant lower (p=0,047) and adiponectin concentrations was higher (p=0,039) in the osteoporosis group. Serum leptin significantly positively correlated with parameters of body composition, serum adiponectin concentrations was negative association with TNFR-1, TNFR-2 (p=0,007). There was a significant inverse relationship between leptin and adiponectin.
Conclusion: These results shows possibly role of adipokines in the increasing of bone loss at the terminal stage of chronic respiratory failure.
- © 2011 ERS