European Respiratory Society

FIGURE 3

Wed, 2022-03-02 09:24 -- admin
Summary: 
Vitamin D metabolism in health and disease. The source of vitamin D includes diet (e.g. milk), sun exposure and supplements. Regardless of source, it is converted to 25-hydroxyvitamin D in the liver. Normally, the enzyme 1-α-hydroxylase metabolises 25-hydroxyvitamin D to calcitriol in the kidney. The activity of 1-α-hydroxylase is regulated by parathyroid hormone (PTH), which responds to serum calcium. In sarcoidosis, 1-α-hydroxylase activity in the granuloma is regulated by IFN. This can lead to excessive serum levels of calcitriol. Reproduced and modified from [1] with permission.
Type: 
Figure
Sub Component: 
Normal
Slug: 
F56
Highwire: Type: 
fragment
HighWire: Journal/Corpus Code: 
ersbk
Highwire: pisa_id: 
ersbk;9781849841467/1/chapter_13/F56
Highwire: pisa_master: 
ersbk;9781849841467/1/chapter_13/F56
HighWire: Atom Path: 
/ersbk/9781849841467/9781849841467/SEC17/F56.atom
Highwire: cpath: 
/content/9781849841467/9781849841467/SEC17/F56
Image - Large: 
Highwire: cpathalias: 
/content/ersbk/9781849841467/9781849841467/SEC17/F56
Image - Medium: 
Highwire: Variants: 
expansion
Image - Small: 
Highwire: State: 
Released
Contributors: 
<atom:author xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" hwp:inherited="yes" nlm:contrib-type="author"><atom:name>Robert P. Baughman</atom:name><atom:email>BAUGHMRP@ucmail.uc.edu</atom:email><nlm:name name-style="western" hwp:sortable="Baughman Robert P."><nlm:surname>Baughman</nlm:surname><nlm:given-names>Robert P.</nlm:given-names></nlm:name></atom:author>
<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" hwp:inherited="yes" nlm:contrib-type="author"><atom:name>Elyse E. Lower</atom:name><nlm:name name-style="western" hwp:sortable="Lower Elyse E."><nlm:surname>Lower</nlm:surname><nlm:given-names>Elyse E.</nlm:given-names></nlm:name></atom:contributor>
Last load event: 
Wednesday, March 2, 2022 - 09:25