European Respiratory Society

Figure 2.

Fri, 2021-07-09 17:29 -- admin
Summary: 
Silica-induced activation of inflammasome and interleukin (IL)-1 production. IL-1α, released from alveolar macrophages following crystalline exposure, results in NF-κB activation and transcription and translation of pro-IL-1β. Phagocytosis of crystalline silica leads to phagosomal damage and release of the phagosome contents into the cytoplasm. This results in the activation of NALP3 (NACHT, LRR, and PYD domains-containing protein 3) and its association with the intracellular adapter protein ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), which combines with and activates pro-caspase-1. The resulting inflammasome cleaves pro-IL-1β to the pro-inflammatory IL-1β. However, binding of immobilised silica crystals to the cell membrane of macrophages is also sufficient to induce IL-1β without evidence of lysosomal damage. Activation of the NALP3 inflammasome by silica also results in efflux of intracellular potassium ions, suggesting a possible interaction of silica with a membrane-associated protein, but it is unclear whether potassium ion efflux following binding of immobilised silica crystals to the cell membrane results in inflammasome activation. Scavenger receptors have a role in the recognition and uptake of silica. Reproduced with kind permission of Michael Pollard, Scripps Research, San Diego, CA, USA.
Type: 
Figure
Sub Component: 
Normal
Slug: 
F33
Highwire: Type: 
fragment
HighWire: Journal/Corpus Code: 
ersbk
Highwire: pisa_id: 
ersbk;9781849841252/1/Chapter_10/F33
Highwire: pisa_master: 
ersbk;9781849841252/1/Chapter_10/F33
HighWire: Atom Path: 
/ersbk/9781849841252/9781849841252/SEC14/F33.atom
Highwire: cpath: 
/content/9781849841252/9781849841252/SEC14/F33
Image - Large: 
Highwire: cpathalias: 
/content/ersbk/9781849841252/9781849841252/SEC14/F33
Image - Medium: 
Image - Small: 
Highwire: Variants: 
expansion
Highwire: State: 
Released
Contributors: 
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