European Respiratory Society

Figure 4.

Fri, 2021-07-09 17:21 -- admin
Summary: 
a) Theoretical model of how the integrated viral burden in the host genome can influence acute and chronic inflammation. Genes contain varying amounts of different integrated viruses (coloured rectangles), which upon gene activation lead to varying amounts of viral expression (coloured circles). The resultant immunological response leads to both acute inflammation and immunosenescence through repeated T-cell activation. b) The immunodeficiency of HIV infection leads to a greater viral burden and more intense as well as more frequent virus re-activations, resulting in frequent rounds of acute inflammation as well as the premature generation of immunosenescent T-cells capable of causing chronic persistent inflammation.
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F26
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