Summary:
Generation of F/HN-pseudotyped lentiviral vector. Sophisticated molecular techniques enable the replacement of the gp120 envelope glycoprotein, which supports lentivirus entry into T-cells but is not suitable for entry into airway epithelial cells, with the F (fusion) and HN (haemagglutinin-neuraminidase) proteins from the Sendai virus, which support efficient entry into airway epithelial cells. This process is called pseudotyping and leads to the generation of a chimeric pseudotyped F/HN lentiviral vector. Figure courtesy of A.C. Boyd, UK CF Gene Therapy Consortium.
Type:
Figure
Sub Component:
Normal
Slug:
F30
Highwire: Type:
fragment
Highwire: Parent:
HighWire: Journal/Corpus Code:
ersbk
Highwire: pisa_id:
ersbk;9781849840514/1/chapter_11/F30
Highwire: pisa_master:
ersbk;9781849840514/1/chapter_11/F30
HighWire: Atom Path:
/ersbk/9781849840514/9781849840514/SEC14/SEC17/F30.atom
Highwire: cpath:
/content/9781849840514/9781849840514/SEC14/SEC17/F30
Image - Large:
Highwire: cpathalias:
/content/ersbk/9781849840514/9781849840514/SEC14/SEC17/F30
Image - Medium:
Highwire: Variants:
expansion
Image - Small:
Highwire: State:
Released
Contributors:
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<atom:contributor xmlns:atom="http://www.w3.org/2005/Atom" xmlns:hwp="http://schema.highwire.org/Journal" xmlns:nlm="http://schema.highwire.org/NLM/Journal" hwp:inherited="yes" nlm:contrib-type="editor"><atom:name>J. Stuart Elborn</atom:name><nlm:name name-style="western" hwp:sortable="Elborn J. Stuart"><nlm:surname>Elborn</nlm:surname><nlm:given-names>J. Stuart</nlm:given-names></nlm:name></atom:contributor>
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