Figure 2

Comparison of the sensitivity and time to diagnosis for active pulmonary tuberculosis (TB) and drug-susceptibility diagnostic tools indicating areas of reduced performance in children and HIV-TB co-infected patients. Only tests commercially available and with a specificity of >95% for the diagnosis of active TB are included. Bactec™ MGIT™ 960 is manufactured by BD Diagnostics (Sparks, MD, USA). Xpert® MTB/RIF is manufactured by Cepheid (Sunnyvale, CA, USA). Amplified MTD® is manufactured by GenProbe (San Diego, CA, USA). GenoType® MTBDRplus is manufactured by Hain Lifescience GmbH (Nehren, Germany). POC: point-of-care; LAM: lipoarabinomannan; NAAT: nucleic acid amplification technique; LAMP: loop isothermal amplification PCR; LPA: line probe assay; DST: drug-susceptibility testing; MODS: microscopy observed drug susceptibility. #: diagnostic test that can be used for both Mycobacterium tuberculosis detection and DST; ¶: LAM lateral flow strip test is restricted to use in HIV-infected patients and will only be commercially available in the fourth quarter of 2012.