Matthew Loza
- Gene set variation analysis of mRNA expression in bronchial biopsies from the U-BIOPRED asthma studyBy Stelios Pavlidis, Anthony Rowe, Ian Adcock, Kirsty Russell, Ioannis Pandis, Yi-Ke Guo, Bertrand DMeuldere, Diane Lefaudeux, Charles Auffray, Ratko Djukanovic, Peter Howarth, Fan Chung, Matthew Loza, Navin Rao and Frédéric BaribaudStelios Pavlidis1Research and Development, Janssen, High Wycombe, Buckinghamshire, United KingdomAnthony Rowe1Research and Development, Janssen, High Wycombe, Buckinghamshire, United KingdomIan Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomKirsty Russell2National Heart & Lung Institute, Imperial College London, London, United KingdomIoannis Pandis3Discovery Sciences Group, Imperial College London, London, United KingdomYi-Ke Guo3Discovery Sciences Group, Imperial College London, London, United KingdomBertrand DMeuldere4European Institute for Systems Biology and Medicine (EISBM), CNRS, Lyon, FranceDiane Lefaudeux4European Institute for Systems Biology and Medicine (EISBM), CNRS, Lyon, FranceCharles Auffray4European Institute for Systems Biology and Medicine (EISBM), CNRS, Lyon, FranceRatko Djukanovic5NIHR, Southampton University, Southampton, United KingdomPeter Howarth5NIHR, Southampton University, Southampton, United KingdomFan Chung2National Heart & Lung Institute, Imperial College London, London, United KingdomMatthew Loza6Research and Development, Janssen, Springhouse,Navin Rao6Research and Development, Janssen, Springhouse,Frédéric Baribaud6Research and Development, Janssen, Springhouse,
- Combined analysis of gene expression and clinical data in the severe asthma U-BIOPRED cohortsBy Bertrand De Meulder, Diane Lefaudeux, Mansoor Saqi, Charles Auffray, Ian Adcock, Fan Chung, Jeanette Bigler, Matthew Loza, Navin Rao, Anthony Rowe, Frédéric Baribaud, Graham Roberts, Ana Sousa, Aruna Bansal, Chris Compton, David Myles, Ratko Djukanovic, Dominic Shaw, Ildiko Horvath, Jacek Musial, Julie Corfield, Pascal Chanez, Norbert Krug, Paolo Montuschi, Per Bakke, Peter Sterk, Riccardo Polosa, Scott Wager, Florian Singer, Stephen Fowler, Sven-Erik Dahlen, Thomas Sandström, Timothy Higenbottam, Ulf Nihlén, Urs Frey and Wolfgang SeiboldBertrand De Meulder1EISBM, CNRS, Lyon, Rhone, FranceDiane Lefaudeux1EISBM, CNRS, Lyon, Rhone, FranceMansoor Saqi1EISBM, CNRS, Lyon, Rhone, FranceCharles Auffray1EISBM, CNRS, Lyon, Rhone, FranceIan Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomFan Chung2National Heart & Lung Institute, Imperial College London, London, United KingdomJeanette Bigler3Amgen Inc, Amgen Inc, Seattle,Matthew Loza4Janssen Research and Development, Janssen, Springhouse,Navin Rao4Janssen Research and Development, Janssen, Springhouse,Anthony Rowe4Janssen Research and Development, Janssen, Springhouse,Frédéric Baribaud4Janssen Research and Development, Janssen, Springhouse,Graham Roberts5University Hospital Southampton NHS Foundation Trust, NHS Foundation Trust, Southampton, United KingdomAna Sousa6Discovery Medicine, GlaxoSmithKline, Uxbridge, United KingdomAruna Bansal7Acclarogen, Acclarogen Ltd, Cambridge, United KingdomChris Compton8Respiratory Development, Novartis, Redhill, United KingdomDavid Myles6Discovery Medicine, GlaxoSmithKline, Uxbridge, United KingdomRatko Djukanovic5University Hospital Southampton NHS Foundation Trust, NHS Foundation Trust, Southampton, United KingdomDominic Shaw9Nottingham University Hospital, Nottingham University Hospital, Nottingham, United KingdomIldiko Horvath10Semmelweis University, Semmelweis University, Budapest, HungaryJacek Musial11Allergy and Immunology, Jagiallonian University, Krakow, PolandJulie Corfield12Areteva, Areteva Ltd, Nottingham, United KingdomPascal Chanez13Clinique des Bronches, Allergie et Sommeil, Université de la Méditerranée, Marseille, FranceNorbert Krug14Immunology, Allergology and Clinical Inhalation, Fraunhofer Institute, Hannover, GermanyPaolo Montuschi15Pharmacology, Università Cattolica del Sacro Cuore, Roma, ItalyPer Bakke16Thoracic Medicine, Haukeland University Hospital, Bergen, SwedenPeter Sterk17Pulmonology, Academisch Medisch Centrum, Amsterdam, NetherlandsRiccardo Polosa18Internal Medicine and Clinical Immunology, University of Catania, Catania, ItalyScott Wager19BioSci Consulting, BioSci Consulting, Maasmechelen, BelgiumFlorian Singer20Paediatric Respiratory Medicine, University Hospital, Inselpital, Bern, SwitzerlandStephen Fowler21Respiratory Research Group, University of Manchester, Manchester, United KingdomSven-Erik Dahlen22Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm, SwedenThomas Sandström23Pulmonology, University Hospital, Umea, SwedenTimothy Higenbottam24Corporate Clinical Development, Chiesi Pharmaceutics Ltd, Cheadle, United KingdomUlf Nihlén25AstraZeneca R&D, AstraZeneca, Södertälje, SwedenUrs Frey20Paediatric Respiratory Medicine, University Hospital, Inselpital, Bern, SwitzerlandWolfgang Seibold26Boehringer Ingelheim, Boehringer Ingelheim Corporation, Ingelheim am Rhein, Germany
- ADEPT-derived, U-BIOPRED validated asthma clinical clusters with Th2 and non-Th2 phenotypesBy Matthew Loza, Philip Silkoff, Vedrana Susilic, Anthony Rowe, Ian Adcock, Charles Auffray, Kian Fan Chung, Ratko Djukanovic, Peter Sterk and Frédéric BaribaudMatthew Loza1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Philip Silkoff1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Vedrana Susilic1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Anthony Rowe1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Ian Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomCharles Auffray3European Institute for Systems Biology and Medicine (EISBM), Centre National de la Recherche Scientifique (CNRS), Campus Charles Mérieux, University of Lyon, Lyon, FranceKian Fan Chung2National Heart & Lung Institute, Imperial College London, London, United KingdomRatko Djukanovic4Academic Unit of Clinical and Experimental Sciences and the NIHR Southampton Respiratory BioMedical Research Unit, Southampton University Hospital, Southampton, United KingdomPeter Sterk5Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, NetherlandsFrédéric Baribaud1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,
- A peripheral HRV-16-driven fingerprint is enriched in severe asthma patients in absence of an active exacerbationBy Patrick Branigan, Ronald Turner, Aleksandar Stojmirovic, Matthew Loza, Alfred Delvecchio, Stanley Marciniak, Nancy Peffer, Philip Silkoff, Radu Dobrin and Frederic BaribaudPatrick Branigan1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Ronald Turner2Division of Infectious Diseases: Pediatric, University of Virginia, Charlottesville, VA,Aleksandar Stojmirovic1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Matthew Loza1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Alfred Delvecchio1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Stanley Marciniak1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Nancy Peffer1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Philip Silkoff1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Radu Dobrin1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,Frederic Baribaud1Systems Pharmacology and Biomarkers, Janssen R&D, Spring House, PA,
- Systemic corticosteroid-associated serum analyte profiles in the U-BIOPRED severe asthma cohortBy Matthew Loza, Stelios Pavlidis, Anthony Rowe, Ratko Djukanovic, Peter Sterk, Ian Adcock, Frédéric Baribaud and K. Fan ChungMatthew Loza1Immunology Research, Janssen Research and Development, Spring House, PA United StatesStelios Pavlidis2Immunology Research, Janssen Research and Development, High Wycombe, United KingdomAnthony Rowe3R&D RSQA IT, Janssen Research and Development, High Wycombe, United KingdomRatko Djukanovic4Faculty of Medicine, Southampton University, Southampton, United KingdomPeter Sterk5Respiratory Medicine, University of Amsterdam, Amsterdam, NetherlandsIan Adcock6National Heart & Lung Institute, Imperial College London, London, United KingdomFrédéric Baribaud1Immunology Research, Janssen Research and Development, Spring House, PA United StatesK. Fan Chung6National Heart & Lung Institute, Imperial College London, London, United Kingdom
- LATE-BREAKING ABSTRACT: Sputum transcriptome analysis yields eosinophilic and non-eosinophilic inflammatory mechanisms in UBIOPRED asthma cohortBy Scott Chih-Hsi Kuo, Yike Guo, Ioannis Pandis, Stelios Pavlidis, Uruji Hoda, Christos Rossios, Julie Corfield, Ana Sousa, Ratko Djukanovic, Matthew Loza, Fred Baribaud, Peter J. Sterk, Ian M Adcock and Kian-Fan ChungScott Chih-Hsi Kuo1National Heart & Lung Institute & Department of Computing, Imperial College, London, United KingdomYike Guo1National Heart & Lung Institute & Department of Computing, Imperial College, London, United KingdomIoannis Pandis1National Heart & Lung Institute & Department of Computing, Imperial College, London, United KingdomStelios Pavlidis2Research and Development, Janssen, High Wycombe, United KingdomUruji Hoda1National Heart & Lung Institute & Department of Computing, Imperial College, London, United KingdomChristos Rossios1National Heart & Lung Institute & Department of Computing, Imperial College, London, United KingdomJulie Corfield3Research and Development, AstraZeneca, Sweden and Areteva, Nottingham, United KingdomAna Sousa4Discovery Medicine, GSK, London, United KingdomRatko Djukanovic5Faculty of Medicine, Southampton University, Southampton, United KingdomMatthew Loza2Research and Development, Janssen, High Wycombe, United KingdomFred Baribaud2Research and Development, Janssen, High Wycombe, United KingdomPeter J. Sterk6Faculty of Medicine, University of Amsterdam, Amsterdam, NetherlandsIan M Adcock1National Heart & Lung Institute & Department of Computing, Imperial College, London, United KingdomKian-Fan Chung1National Heart & Lung Institute & Department of Computing, Imperial College, London, United Kingdom
- Inflammatory serum profiles are consistent across independent exacerbations in COPD patients with a history of frequent exacerbationsBy Alexander Mackay, Matthew Loza, Patrick Branigan, Siobhan George, Gavin Donaldson, Frederic Baribaud and Jadwiga WedzichaAlexander Mackay1Centre for Respiratory Medicine, UCL Medical School, Royal Free Campus, London, United KingdomMatthew Loza2Janssen Research & Development, Janssen Research & Development, Spring House, United StatesPatrick Branigan2Janssen Research & Development, Janssen Research & Development, Spring House, United StatesSiobhan George3Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomGavin Donaldson3Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomFrederic Baribaud2Janssen Research & Development, Janssen Research & Development, Spring House, United StatesJadwiga Wedzicha3Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Clinical biomarkers identify T-helper 2 status defined by mucosal CCL26 in the ADEPT-asthma studyBy Matthew Loza, Irina Strambu, Michel Laviolette, David Singh, J. Mark FitzGerald, Stephen Lam, Steven Steven Kelsen, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Patrick Berger, Richard Leigh, Joel Kline, Mark Dransfield, William Calhoun, Azra Hussaini, Sumita Khatri, Pascal Chanez, Vedrana Susulic, Elliot Barnathan, Kevin Petty, Mark Curran, Anuk Das, Carrie Brodmerkel, Frédéric Baribaud and Philip SilkoffMatthew Loza1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesIrina Strambu2ARENSIA and University of Medicine and Pharmacy Bucharest, Bucharest, RomaniaMichel Laviolette3Centre de Recherche de l'IUC PQ, Université Laval, Quebec, QC CanadaDavid Singh4Medicines Evaluation Unit, University Hospital of South Manchester, Manchester, United KingdomJ. Mark FitzGerald5Institute of Heart and Lung Health, University of British Columbia, Vancouver, BC CanadaStephen Lam5Institute of Heart and Lung Health, University of British Columbia, Vancouver, BC CanadaSteven Steven Kelsen6Department of Medicine, Temple University, Philadelphia, PA United StatesAndreas Eich7Institute für Klinische Forschung Frankfurt, Institute für Klinische Forschung Frankfurt, Frankfurt, GermanyAndrea Ludwig-Sengpiel8KLB Gesundheitsforschung Lübeck, KLB Gesundheitsforschung Lübeck, Lübeck, GermanyGeoffrey Chupp9Medicine - Pulmonary, Yale University, New Haven, CT United StatesVibeke Backer10Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, DenmarkCeleste Porsbjerg10Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, DenmarkPierre-Olivier Girodet11Medicine, University of Bordeaux, Bordeaux, FrancePatrick Berger11Medicine, University of Bordeaux, Bordeaux, FranceRichard Leigh12Medicine and Physiology and Pharmacology, University of Calgary, Calgary, AB CanadaJoel Kline13Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, Iowa City, IA United StatesMark Dransfield14Medicine, The University of Alabama at Birmingham, Birmingham, AL United StatesWilliam Calhoun15Internal Medicine, University of Texas Medical Branch, Galveston, TX United StatesAzra Hussaini16Parexel International, Parexel International, Baltimore, MD United StatesSumita Khatri17Pathobiology, Cleveland Clinic, Cleveland, OH United StatesPascal Chanez18Service de Pneumo-Allergologie, Université de la Méditerranée, Marseille, FranceVedrana Susulic1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesElliot Barnathan1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesKevin Petty1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesMark Curran1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesAnuk Das1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesCarrie Brodmerkel1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesFrédéric Baribaud1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United StatesPhilip Silkoff1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA United States
- Increased interferon and decreased NRF2-PPARG signaling is associated with frequent exacerbations in COPDBy Huiqing Liu, Matthew Loza, Alexander Mackay, Patrick Branigan, Nancy Peffer, Swetha Patel, Gavin Donaldson, Siobhan George, Frederic Baribaud and Jadwiga WedzichaHuiqing Liu1Immunology Pulmonary, Janssen Research & Development, Spring House, PA United StatesMatthew Loza1Immunology Pulmonary, Janssen Research & Development, Spring House, PA United StatesAlexander Mackay2UCL Medical School, Royal Free Campus, London, United KingdomPatrick Branigan1Immunology Pulmonary, Janssen Research & Development, Spring House, PA United StatesNancy Peffer1Immunology Pulmonary, Janssen Research & Development, Spring House, PA United StatesSwetha Patel1Immunology Pulmonary, Janssen Research & Development, Spring House, PA United StatesGavin Donaldson3Respiratory Medicine, Imperial College, London, United KingdomSiobhan George3Respiratory Medicine, Imperial College, London, United KingdomFrederic Baribaud1Immunology Pulmonary, Janssen Research & Development, Spring House, PA United StatesJadwiga Wedzicha3Respiratory Medicine, Imperial College, London, United Kingdom
- A murine ovalbumin model exhibits molecular features of steroid insensitive human asthmaBy Frédéric Baribaud, Huiqing Liu, Patrick Branigan, Daniel Horowitz, Yanqing Chen, Joshua Wertheimer, Joel Tocker and Matthew LozaFrédéric BaribaudImmunology Research, Janssen R&D, Springhouse, PA United StatesHuiqing LiuImmunology Research, Janssen R&D, Springhouse, PA United StatesPatrick BraniganImmunology Research, Janssen R&D, Springhouse, PA United StatesDaniel HorowitzImmunology Research, Janssen R&D, Springhouse, PA United StatesYanqing ChenImmunology Research, Janssen R&D, Springhouse, PA United StatesJoshua WertheimerImmunology Research, Janssen R&D, Springhouse, PA United StatesJoel TockerImmunology Research, Janssen R&D, Springhouse, PA United StatesMatthew LozaImmunology Research, Janssen R&D, Springhouse, PA United States
- Th2 subsetting of U-BIOPRED asthma subjects based on airway transciptomic profilesBy Stelios Pavlidis, Matthew Loza, Frédéric Baribaud, Chih-Hsi Kuo, Anthony Rowe, Rene Lutter, Uruj Hoda, Christos Rossios, Ana Sousa, Julie Corfield, Ian Adcock, Ratko Djukanovic, Peter Sterk and Fan ChungStelios Pavlidis1Research and Development, Janssen, High Wycombe, Buckinghamshire United KingdomMatthew Loza2Immunology Biomarkers, Janssen, Ambler, PA United StatesFrédéric Baribaud2Immunology Biomarkers, Janssen, Ambler, PA United StatesChih-Hsi Kuo3National Heart & Lung Institute, Imperial College London, London, United KingdomAnthony Rowe1Research and Development, Janssen, High Wycombe, Buckinghamshire United KingdomRene Lutter4Academic Medical Center, University of Amsterdam, Amsterdam, NetherlandsUruj Hoda3National Heart & Lung Institute, Imperial College London, London, United KingdomChristos Rossios3National Heart & Lung Institute, Imperial College London, London, United KingdomAna Sousa5Director of Discovery, GlaxoSmithKline, London, United KingdomJulie Corfield6Biobanking, R&D, Areteva, Nottingham, United KingdomIan Adcock3National Heart & Lung Institute, Imperial College London, London, United KingdomRatko Djukanovic7Southampton Centre for Biomedical Research, University of Southampton School of Medicine, Southampton, United KingdomPeter Sterk4Academic Medical Center, University of Amsterdam, Amsterdam, NetherlandsFan Chung3National Heart & Lung Institute, Imperial College London, London, United Kingdom
- Identification of molecular pathways in distinct asthma phenotypes identified in ADEPTBy Carl Manthey, Vy Hoang, Michael Macoritto, Matthew Loza, Fréedéric Baribaud and Joel TockerCarl Manthey1Immunology, Janssen Research & Development, Spring House, PA United StatesVy Hoang2Computational Biology, Selventa, Cambridge, MA United StatesMichael Macoritto2Computational Biology, Selventa, Cambridge, MA United StatesMatthew Loza1Immunology, Janssen Research & Development, Spring House, PA United StatesFréedéric Baribaud1Immunology, Janssen Research & Development, Spring House, PA United StatesJoel Tocker1Immunology, Janssen Research & Development, Spring House, PA United States
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