Thomas Illig
- CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung diseaseBy Michael S.D. Kormann, Andreas Hector, Veronica Marcos, Lauren E. Mays, Matthias Kappler, Thomas Illig, Norman Klopp, Sonja Zeilinger, Melanie Carevic, Nikolaus Rieber, Olaf Eickmeier, Stefan Zielen, Amit Gaggar, Barbara Moepps, Matthias Griese and Dominik HartlMichael S.D. KormannAndreas HectorVeronica MarcosLauren E. MaysMatthias KapplerThomas IlligNorman KloppSonja ZeilingerMelanie CarevicNikolaus RieberOlaf EickmeierStefan ZielenAmit GaggarBarbara MoeppsMatthias Griese
- Genetic variations in the TLR signaling pathway are associated with childhood asthmaBy Ramesh Chandra Pandey, Sven Michel, Riccardina Tesse, Aristea Binia, Michaela Schedel, Liming Liang, Norman Klopp, Erika von Mutius, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Otto Laub, Burkhard Simma, Thomas Frischer, Jon Genuneit, Thomas Illig and Michael KabeschRamesh Chandra Pandey1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanySven Michel1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyRiccardina Tesse1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyAristea Binia1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyMichaela Schedel1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyLiming Liang2Department of Epidemiology, Harvard School of Public Health, Boston, United StatesNorman Klopp3Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany4Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyErika von Mutius5University Children's Hospital, Ludwig Maximilian's University, Munich, GermanyAndrea von Berg6Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, GermanyAlbrecht Bufe7Department of Experimental Pneumology, Ruhr-University, Bochum, GermanyErnst Rietschel8University Children's Hospital, University of Cologne, GermanyAndrea Heinzmann9University Children's Hospital, Albert Ludwigs University, Freiburg, GermanyOtto Laub10Kinder- und Jugendarztpraxis Laub, Kinder- und Jugendarztpraxis Laub, Rosenheim, GermanyBurkhard Simma11Children's Department, University Teaching Hospital Landeskrankenhaus, Feldkirch, AustriaThomas Frischer12University Children's Hospital, University Children's Hospital, Vienna, AustriaJon Genuneit13Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyThomas Illig3Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany4Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyMichael Kabesch1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
- A polymorphism in DMRT1 is associated with asthma in boys only and affects promoter activity by allele-specific transcription factor bindingBy Maximilian Schieck, Jan P. Schouten, Kathrin Suttner, Sven Michel, Philip Rosenstiel, Normann Klopp, Thomas Illig, Jon Genuneit, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Thomas Frischer, Otto Laub, Ernst Rietschel, Burkhard Simma, Erika von Mutius, Marike Boezen and Michael KabeschMaximilian Schieck1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyJan P. Schouten16Department of Epidemiology, University Medical Center Groningen, University of Groningen, NetherlandsKathrin Suttner1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany2Center of Allergy and Environment, Technical University Munich and Helmholtz Center, Munich, GermanySven Michel1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyPhilip Rosenstiel3Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, GermanyNormann Klopp4Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany5Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyThomas Illig4Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany5Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyJon Genuneit6Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyChristian Vogelberg7University Children's Hospital, Technical University, Dresden, GermanyAndrea von Berg8Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, GermanyAlbrecht Bufe9Department of Experimental Pneumology, Ruhr-University, Bochum, GermanyAndrea Heinzmann10University Children's Hospital, Albert Ludwigs University, Freiburg, GermanyThomas Frischer11University Children's Hospital, University Children's Hospital, Vienna, AustriaOtto Laub12Kinder- und Jugendarztpraxis Laub, Kinder- und Jugendarztpraxis Laub, Rosenheim, GermanyErnst Rietschel13University Children's Hospital, University of Cologne, GermanyBurkhard Simma14Children's Department, University Teaching Hospital Landeskrankenhaus, Feldkirch, AustriaErika von Mutius15University Children's Hospital, Ludwig Maximilians University, Munich, GermanyMarike Boezen16Department of Epidemiology, University Medical Center Groningen, University of Groningen, NetherlandsMichael Kabesch1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
- IgE levels in asthmatics and non-asthmatics are affected by different SNPs in FCER1ABy Daniel P. Potaczek, Sven Michel, Vishwas Sharma, Michaela Kolletzki, Norman Klopp, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Thomas Frischer, Jon Genuneit, Thomas Illig, Erika von Mutius and Michael KabeschDaniel P. Potaczek1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany13University Children's Hospital, Ludwig Maximilians University, Munich, GermanySven Michel1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany13University Children's Hospital, Ludwig Maximilians University, Munich, GermanyVishwas Sharma1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyMichaela Kolletzki1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyNorman Klopp2Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany3Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyChristian Vogelberg4University Children's Hospital, Technical University, Dresden, GermanyAndrea von Berg5Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, GermanyAlbrecht Bufe6Department of Experimental Pneumology, Ruhr-University, Bochum, GermanyAndrea Heinzmann7University Children's Hospital, Albert Ludwigs University, Freiburg, GermanyOtto Laub8Kinder- und Jugendarztpraxis Laub, Kinder- und Jugendarztpraxis Laub, Rosenheim, GermanyErnst Rietschel9University Children's Hospital, University of Cologne, GermanyBurkhard Simma10Children's Department, University Teaching Hospital, Landeskrankenhaus Feldkirch, AustriaThomas Frischer11University Children's Hospital, University Children's Hospital, Vienna, AustriaJon Genuneit12Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyThomas Illig2Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany3Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyErika von Mutius13University Children's Hospital, Ludwig Maximilians University, Munich, GermanyMichael Kabesch1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
- Genetic variants in Protocadherin-1, bronchial hyperresponsiveness and asthma subphenotypes in German childrenBy Antoaneta Toncheva, Kathrin Suttner, Sven Michel, Norman Klopp, Thomas Illig, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Thomas Frischer, Jon Genuneit, Erika von Mutius and Michael KabeschAntoaneta Toncheva1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany13University Children's Hospital, Ludwig Maximilians University, Munich, GermanyKathrin Suttner1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany13University Children's Hospital, Ludwig Maximilians University, Munich, GermanySven Michel1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany13University Children's Hospital, Ludwig Maximilians University, Munich, GermanyNorman Klopp2Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany3Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyThomas Illig2Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany3Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyChristian Vogelberg4University Children's Hospital, Technical University, Dresden, GermanyAndrea von Berg5Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, GermanyAlbrecht Bufe6Department of Experimental Pneumology,, Ruhr-University, Bochum, GermanyAndrea Heinzmann7University Children's Hospital, Albert Ludwigs University, Freiburg, GermanyOtto Laub8Kinder- und Jugendarztpraxis Laub, Kinder- und Jugendarztpraxis Laub, Rosenheim, GermanyErnst Rietschel9University Children's Hospital, University of Cologne, GermanyBurkhard Simma10Children's Department, University Teaching Hospital Landeskrankenhaus, Feldkirch, AustriaThomas Frischer11University Children's Hospital, University Children's Hospital, Vienna, AustriaJon Genuneit12Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyErika von Mutius13University Children's Hospital, Ludwig Maximilians University, Munich, GermanyMichael Kabesch1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
- Polymorphisms in all three ORMDL genes are associated with asthma and their mRNA expression is increased in asthmaticsBy Antoaneta Toncheva, Daniel Potaczek, Michaela Schedel, Sven Michel, Natalie Krajnov, Vincent Gaertner, Thomas Illig, Andre Franke, Carla Winkler, Jens Hohlfeld, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Jon Genuneit and Michael KabeschAntoaneta Toncheva1Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany2Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyDaniel Potaczek2Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyMichaela Schedel2Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany3Department of Pediatrics, National Jewish Health, Denver, CO,Sven Michel1Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany2Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyNatalie Krajnov2Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanyVincent Gaertner1Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, GermanyThomas Illig4Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany5Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyAndre Franke6Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, GermanyCarla Winkler7Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany8Department of Respiratory Medicine, Hannover Medical School, Hannover, GermanyJens Hohlfeld7Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany8Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany17German Lung Research Center (DZL), German Lung Research Center, Hannover, GermanyChristian Vogelberg9University Children’s Hospital, Technical University Dresden, Dresden, GermanyAndrea von Berg10Research Institute for the Prevention of Allergic Diseases, Children’s Department, Marien-Hospital, Wesel, GermanyAlbrecht Bufe11Department of Experimental Pneumology, Ruhr-University, Bochum, GermanyAndrea Heinzmann12University Children’s Hospital, Albert Ludwigs University, Freiburg, GermanyOtto Laub13Kinder- und Jugendarztpraxis Laub, Kinder- und Jugendarztpraxis Laub, Rosenheim, GermanyErnst Rietschel14University Children’s Hospital, University of Cologne, Cologne, GermanyBurkhard Simma15Children’s Department, University Teaching Hospital, Landeskrankenhaus Feldkirch, Feldkirch, AustriaJon Genuneit16Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyMichael Kabesch1Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany2Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany17German Lung Research Center (DZL), German Lung Research Center, Hannover, Germany
- Fine-mapping of IgE associated loci 1q23, 5q31 and 12q13By Vishwas Sharma, Sven Michel, Vincent Gaertner, Andre Franke, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Thomas Frischer, Jon Genuneit, Sonja Zeilinger, Thomas Illig, Michaela Schedel, Daniel Potaczek and Michael KabeschVishwas Sharma1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, GermanySven Michel1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany2Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, GermanyVincent Gaertner2Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, GermanyAndre Franke3Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, GermanyChristian Vogelberg4University Children's Hospital, Technical University Dresden, Dresden, GermanyAndrea von Berg5Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital Wesel, Wesel, GermanyAlbrecht Bufe6Department of Experimental Pneumology, Ruhr-University, Bochum, GermanyAndrea Heinzmann7University Children's Hospital, Albert Ludwigs University, Freiburg, GermanyOtto Laub8Kinder- und Jugendarztpraxis, Laub, Rosenheim, GermanyErnst Rietschel9University Children's Hospital, University of Cologne, Cologne, GermanyBurkhard Simma10Children's Department, University Teaching Hospital, Landeskrankenhaus Feldkirch, Feldkirch, AustriaThomas Frischer11University Children's Hospital Vienna, Vienna, AustriaJon Genuneit12Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanySonja Zeilinger13Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, GermanyThomas Illig13Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany14Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyMichaela Schedel15Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver,Daniel Potaczek16Institute of Laboratory Medicine, Philipps-Universität Marburg, Marburg, GermanyMichael Kabesch1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany2Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany17Member of the German Lung Research Center, (DZL), Germany
- Are metabolomic markers associated with spirometric lung function indices?By Claudia Flexeder, Stefan Karrasch, Gabi Kastenmüller, Christa Meisinger, Ann-Kristin Petersen, Elisabeth Thiering, Cornelia Prehn, Rui Wang-Sattler, Stephan Weidinger, Christian Gieger, Joachim Heinrich, Rolf Holle, Annette Peters, Thomas Illig, Jerzy Adamski, Karsten Suhre and Holger SchulzClaudia Flexeder1Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, GermanyStefan Karrasch1Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany2Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-University, Munich, Germany3Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, GermanyGabi Kastenmüller4Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, GermanyChrista Meisinger5Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, GermanyAnn-Kristin Petersen6Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, GermanyElisabeth Thiering1Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, GermanyCornelia Prehn7Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, GermanyRui Wang-Sattler8Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, GermanyStephan Weidinger9Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, GermanyChristian Gieger6Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, GermanyJoachim Heinrich1Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany10Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, GermanyRolf Holle11Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg, GermanyAnnette Peters5Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, GermanyThomas Illig8Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany12Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyJerzy Adamski7Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany13Chair of Experimental Genetics, Technische Universität München, Munich, GermanyKarsten Suhre4Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany14Department of Physiology and Biophysics, Weill Cornell Medical College, Education City, QatarHolger Schulz1Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany
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