Holger Garn
- Late-breaking abstract: Local and systemic distribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposureBy Agnieszka Turowska, Nadja Baumgartl, Jens Kuhlmann and Holger GarnAgnieszka Turowska1Sterna Biologicals GmbH & Co.KG, Biomedizinisches Forschungszentrum (BMFZ), Marburg, GermanyNadja Baumgartl2Institute of Laboratory Medicine and Pathobiochemistry - Molecular Diagnostics, Medical Faculty, Philips University of Marburg, Marburg, GermanyJens Kuhlmann2Institute of Laboratory Medicine and Pathobiochemistry - Molecular Diagnostics, Medical Faculty, Philips University of Marburg, Marburg, Germany
- Safety profile and pharmacokinetics of an inhaled GATA-3-specific DNAzyme in a first-in man study in healthy subjectsBy Wolfgang Timmer, Klaus Kutz, Gerhard Schlüter, Friedeborg Seitz, Uwe Wannenwetsch, Jens Kuhlmann, Manuela Stauss-Grabo, Anja Zensi, Oliver Schmidt, Gerhard Breipohl, Harald Renz, Joachim Bille, Ursula Homburg and Holger GarnWolfgang Timmer2Clinical Research Services, CRS Clinical Research Services Mannheim GmbH, Mannheim, GermanyKlaus Kutz3Advisor Clinical Pharmacology, AccelPharm, Basel, SwitzerlandGerhard Schlüter4Consultant Toxicology, GS, Wuppertal, GermanyFriedeborg Seitz2Clinical Research Services, CRS Clinical Research Services Mannheim GmbH, Mannheim, GermanyUwe Wannenwetsch2Clinical Research Services, CRS Clinical Research Services Mannheim GmbH, Mannheim, GermanyJens Kuhlmann1R&D, Sterna Biologicals GmbH, Marburg, GermanyManuela Stauss-Grabo5R&D, Engelhard Arzneimittel GmbH & Co KG, Niederdorfelden, GermanyAnja Zensi5R&D, Engelhard Arzneimittel GmbH & Co KG, Niederdorfelden, GermanyOliver Schmidt5R&D, Engelhard Arzneimittel GmbH & Co KG, Niederdorfelden, GermanyGerhard Breipohl6Chemistry, Manufacturing & Controls Consulting, GB, Hilden, GermanyHarald Renz7University Hospital Giessen and Marburg GmbH, Institute of Laboratory Medicine and Pathobiochemistry, Philipps University Marburg, Marburg, GermanyJoachim Bille1R&D, Sterna Biologicals GmbH, Marburg, GermanyUrsula Homburg1R&D, Sterna Biologicals GmbH, Marburg, GermanyHolger Garn8Institute of Laboratory Medicine and Pathobiochemistry, Philipps University Marburg, Marburg, Germany
- Analysis of IL-6 function in transmaternal asthma protection induced by Acinetobacter IwoffiiBy Dörthe Andrea Kesper, Olaf Pinkenburg, Petra Ina Pfefferle, Holger Garn and Harald RenzDörthe Andrea Kesper1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps-University, Marburg, GermanyOlaf Pinkenburg2Insitute for Immunology, Philipps-University, Marburg, GermanyPetra Ina Pfefferle1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps-University, Marburg, GermanyHolger Garn1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps-University, Marburg, GermanyHarald Renz1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps-University, Marburg, Germany
- Advantageous toxicity profile of an inhaled GATA-3-specific DNAzyme intended for anti-inflammatory treatment of Th2-driven asthmaBy Rainer Fuhst, Frank Runge, Jochen Buschmann, Christiane Praechter, Jasmin von Erichsen, Agnieszka Turowska, Heinz-Gerd Hoymann, Meike Müller, Gerhard Pohlmann, Katherina Sewald, Christina Ziemann, Gerhard Schlüter and Holger GarnRainer Fuhst1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyFrank Runge2Institute of Pharmacology and Preclinical Drug Safety, Nycomed, Barsbüttel, GermanyJochen Buschmann1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyChristiane Praechter2Institute of Pharmacology and Preclinical Drug Safety, Nycomed, Barsbüttel, GermanyJasmin von Erichsen2Institute of Pharmacology and Preclinical Drug Safety, Nycomed, Barsbüttel, GermanyAgnieszka Turowska3R&D, Sterna Biologicals, Marburg, GermanyHeinz-Gerd Hoymann1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyMeike Müller1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyGerhard Pohlmann1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyKatherina Sewald1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyChristina Ziemann1General and Reproductive Toxicology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, GermanyGerhard Schlüter4Toxicology, Independent Consultant, Wuppertal, GermanyHolger Garn5Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University, Marburg, Germany
- Allergyprotective effects of Staphylococcus scuiri in a house dust mite (HDM) model of allergic airway inflammationBy Stefanie Hagner, Min Zhao, Hani Harb, Harald Renz, Petra Pfefferle and Holger GarnStefanie Hagner1Medicine, Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Biomedical Research Center (BMFZ), Marburg, GermanyMin Zhao1Medicine, Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Biomedical Research Center (BMFZ), Marburg, GermanyHani Harb1Medicine, Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Biomedical Research Center (BMFZ), Marburg, GermanyHarald Renz1Medicine, Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Biomedical Research Center (BMFZ), Marburg, GermanyPetra Pfefferle1Medicine, Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Biomedical Research Center (BMFZ), Marburg, GermanyHolger Garn1Medicine, Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Biomedical Research Center (BMFZ), Marburg, Germany
- Autoimmune induction of a COPD-like inflammatory phenotype in miceBy Nadja Baumgartl, Holger Garn, Agnieszka Turowska and Norbert WeissmannNadja Baumgartl1Philipps University Marburg, Institute of Laboratory Medicine and Pathobiochemistry, Marburg, GermanyHolger Garn1Philipps University Marburg, Institute of Laboratory Medicine and Pathobiochemistry, Marburg, GermanyAgnieszka Turowska2R&D, Sterna Biologicals, Marburg, GermanyNorbert Weissmann3Justus-Liebig University Gießen, Excellence Cluster Cardiopulmonary System, Gießen, Germany
- Safety profile and pharmacokinetics of SB010, an inhaled GATA-3-specific DNAzyme, in phase I clinical trials in healthy and asthmatic subjectsBy Ursula Homburg, Agnieszka Turowska, Jens Kuhlmann, Anke Müller, Jonas Renz, Joachim Bille, Harald Renz and Holger GarnUrsula Homburg1R&D, Sterna Biologicals GmbH & Co. KG, Marburg, GermanyAgnieszka Turowska1R&D, Sterna Biologicals GmbH & Co. KG, Marburg, GermanyJens Kuhlmann1R&D, Sterna Biologicals GmbH & Co. KG, Marburg, GermanyAnke Müller1R&D, Sterna Biologicals GmbH & Co. KG, Marburg, GermanyJonas Renz1R&D, Sterna Biologicals GmbH & Co. KG, Marburg, GermanyJoachim Bille1R&D, Sterna Biologicals GmbH & Co. KG, Marburg, GermanyHarald Renz2Institute of Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Marburg, GermanyHolger Garn2Institute of Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Marburg, Germany
- Systemic characterization of macrophage phenotypes in allergic airway inflammationBy Wilhelm Bertrams, Kerstin Seidel, Alexandra Sittka, Annalisa Marsico, Stefanie Hagner-Benes, Holger Garn, Harald Renz, Martin Vingron and Bernd SchmeckWilhelm Bertrams1Institute for Lung Research, Philipps University Marburg, Marburg, Hessen, GermanyKerstin Seidel1Institute for Lung Research, Philipps University Marburg, Marburg, Hessen, GermanyAlexandra Sittka1Institute for Lung Research, Philipps University Marburg, Marburg, Hessen, GermanyAnnalisa Marsico2Bioinformatics, Max Plack Institute for Molecular Genetics, Berlin, GermanyStefanie Hagner-Benes3Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Hessen, GermanyHolger Garn3Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Hessen, GermanyHarald Renz3Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Hessen, GermanyMartin Vingron2Bioinformatics, Max Plack Institute for Molecular Genetics, Berlin, GermanyBernd Schmeck1Institute for Lung Research, Philipps University Marburg, Marburg, Hessen, Germany
- Late-breaking abstract: Attenuation of allergen-induced asthmatic responses by inhaled GATA-3 specific DNAzymeBy Holger Garn, Norbert Krug, Jens Hohlfeld, Anne-Marie Kirsten, Oliver Kornmann, Kai Beeh, Dominik Kappeler, Stephanie Korn, Stanislav Ignatenko, Cordelia Rogon, Joachim Bille, Ursula Homburg, Agnieszka Turowska, Roland Buhl, Jonas Renz and Harald RenzHolger Garn10Institute of Laboratory Medicine, Philipps University Marburg, Marburg, GermanyNorbert Krug1Airway Research, Fraunhofer ITEM, Hannover, GermanyJens Hohlfeld1Airway Research, Fraunhofer ITEM, Hannover, GermanyAnne-Marie Kirsten2Pulmonary Research Institute, Lung Clinic Großhansdorf, Großhansdorf, GermanyOliver Kornmann3IKF Pneumologie GmbH & Co. KG, Clinical Research Center Respiratory Diseases, Frankfurt, GermanyKai Beeh4Insaf Respiratory Research Institute, Wiesbaden, GermanyDominik Kappeler5INAMED GmbH, Gauting, GermanyStephanie Korn6Pulmonary Department, Medical Clinic, University Hospital Mainz, Mainz, GermanyStanislav Ignatenko7Charité Research Organization GmbH, Berlin, GermanyCordelia Rogon8FGK Clinical Research GmbH, Munich, GermanyJoachim Bille9Sterna Biologicals GmbH & Co. KG, Marburg, GermanyUrsula Homburg9Sterna Biologicals GmbH & Co. KG, Marburg, GermanyAgnieszka Turowska9Sterna Biologicals GmbH & Co. KG, Marburg, GermanyRoland Buhl6Pulmonary Department, Medical Clinic, University Hospital Mainz, Mainz, GermanyJonas Renz9Sterna Biologicals GmbH & Co. KG, Marburg, GermanyHarald Renz10Institute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany
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The ERS Monograph is the quarterly book series from the European Respiratory Society. Each Monograph covers a specific area of respiratory medicine, providing in-depth reviews that give clinicians at all levels a concise, comprehensive guide to symptoms, diagnosis and treatment.
The ERS Handbooks are compact guides to broad areas of the respiratory field. Launched in 2010, the series now covers adult, paediatric and sleep respiratory medicine, includes a companion volume of self-assessment questions and features the ERS Practical Handbooks.