Ian Adcock
- Inhibition of glycogen synthase kinase 3beta reduces GC function in human monocytes via modulation of HDAC2 activityBy Anta Ngkelo, Laurie Stevens, Mike Yeadon, Iain Kilty, Ian Adcock and Paul KirkhamAnta Ngkelo1Airway Disease Section, NHLI, Imperial College, London, United KingdomLaurie Stevens2Reserach and Develpment, Pfizer, Sandwich, United KingdomMike Yeadon2Reserach and Develpment, Pfizer, Sandwich, United KingdomIain Kilty2Reserach and Develpment, Pfizer, Sandwich, United KingdomIan Adcock1Airway Disease Section, NHLI, Imperial College, London, United KingdomPaul Kirkham1Airway Disease Section, NHLI, Imperial College, London, United Kingdom
- Hypoxia Inducible Factor-1α binding to HDAC2 and MIF promoter regions is associated with changes in gene expression levels in chronic ozone exposed miceBy Coen Wiegman, Kirsty Russell, Colin Clarke, Peter Barnes and Ian AdcockCoen WiegmanAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomKirsty RussellAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomColin ClarkeAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomPeter BarnesAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomIan AdcockAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Fluticasone furoate, a novel corticosteroid, maintains glucocorticoid receptor nuclear localisation for 24 hours after washout in monocytesBy Amir Hakim, Malcolm Johnson, Peter Barnes, Ian Adcock and Omar UsmaniAmir HakimNational Heart & Lung Institute, Imperial College, London, United KingdomMalcolm JohnsonNational Heart & Lung Institute, Imperial College, London, United KingdomPeter BarnesNational Heart & Lung Institute, Imperial College, London, United KingdomIan AdcockNational Heart & Lung Institute, Imperial College, London, United KingdomOmar UsmaniNational Heart & Lung Institute, Imperial College, London, United Kingdom
- Klotho: An important protein in the formation and development of emphysemaBy Xin Yao, Cheng Yuan, Jingying Zhang, Lin Zhou, Mao Huang, Ian Adcock and Peter BarnesXin Yao1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, JIangsu, ChinaCheng Yuan1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, JIangsu, ChinaJingying Zhang1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, JIangsu, ChinaLin Zhou1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, JIangsu, ChinaMao Huang1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, JIangsu, ChinaIan Adcock2Airway Disease, NHLI, Impeial College, London, United KingdomPeter Barnes2Airway Disease, NHLI, Impeial College, London, United Kingdom
- Dexamethasone induces anti-remodelling effects in rat pulmonary arterial smooth muscle cellsBy Laura Price, Frederic Perros, Dongmin Shao, Jie Zhu, David Montani, Peter Dorfmuller, John Wharton, Marc Humbert, Ian Adcock and John WortLaura Price1Department of Pulmonary Hypertension, Royal Brompton Hospital, London, United KingdomFrederic Perros2Service de Pneumologie et Réanimation Respiratoire, Centre National de Référence de l'Hypertension Pulmonaire Sévère, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique Hôpitaux de Paris 157, Rue de la Porte de Tr, Clamart, Paris, FranceDongmin Shao1Department of Pulmonary Hypertension, Royal Brompton Hospital, London, United KingdomJie Zhu3Department of Histology, Royal Brompton Hospital, London, United KingdomDavid Montani2Service de Pneumologie et Réanimation Respiratoire, Centre National de Référence de l'Hypertension Pulmonaire Sévère, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique Hôpitaux de Paris 157, Rue de la Porte de Tr, Clamart, Paris, FrancePeter Dorfmuller2Service de Pneumologie et Réanimation Respiratoire, Centre National de Référence de l'Hypertension Pulmonaire Sévère, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique Hôpitaux de Paris 157, Rue de la Porte de Tr, Clamart, Paris, FranceJohn Wharton4Section on Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, United KingdomMarc Humbert2Service de Pneumologie et Réanimation Respiratoire, Centre National de Référence de l'Hypertension Pulmonaire Sévère, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique Hôpitaux de Paris 157, Rue de la Porte de Tr, Clamart, Paris, FranceIan Adcock5Cell & Molecular Biology Airways Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United KingdomJohn Wort1Department of Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom
- The role of bromodomain-containing protein 4 in the constitutive activation of nuclear factor-kappa B in endothelial cells from patients with pulmonary arterial hypertensionBy Natalia Gambaryan, Christophe Guignabert, Ly Tu, Frederic Perros, Ian Adcock, Marc Humbert and Stephen WortNatalia Gambaryan1INSERM U999, Centre Chirurgical Marie Lannelongue, Université Paris-Sud 11, Le Plessis-Robinson, FranceChristophe Guignabert1INSERM U999, Centre Chirurgical Marie Lannelongue, Université Paris-Sud 11, Le Plessis-Robinson, FranceLy Tu1INSERM U999, Centre Chirurgical Marie Lannelongue, Université Paris-Sud 11, Le Plessis-Robinson, FranceFrederic Perros1INSERM U999, Centre Chirurgical Marie Lannelongue, Université Paris-Sud 11, Le Plessis-Robinson, FranceIan Adcock2Department of Critical Care, National Heart and Lung Institute, Imperial College, London, United KingdomMarc Humbert1INSERM U999, Centre Chirurgical Marie Lannelongue, Université Paris-Sud 11, Le Plessis-Robinson, FranceStephen Wort2Department of Critical Care, National Heart and Lung Institute, Imperial College, London, United Kingdom
- NFAT subtypes in regulating Th2 lymphocytesBy Xin Yao, Yue Teng, Hao Huang, Ian Adcock and Peter BarnesXin Yao1Respiratory Medicine, The First Affliliated Hospital of Nanjing Medical University, Nanjing, ChinaYue Teng1Respiratory Medicine, The First Affliliated Hospital of Nanjing Medical University, Nanjing, ChinaHao Huang1Respiratory Medicine, The First Affliliated Hospital of Nanjing Medical University, Nanjing, ChinaIan Adcock2Airway Disease, NHLI, Imperial College, London, United KingdomPeter Barnes2Airway Disease, NHLI, Imperial College, London, United Kingdom
- Bromodomain mimics reduce oxidative stress-induced inflammation in human epithelial cellsBy Younis Khan, Paul Kirkham and Ian AdcockYounis Khan1Airway Disease Section, National Lung and Heart Institution, Imperial College London, London, United KingdomPaul Kirkham1Airway Disease Section, National Lung and Heart Institution, Imperial College London, London, United KingdomIan Adcock1Airway Disease Section, National Lung and Heart Institution, Imperial College London, London, United Kingdom
- H3K27 histone lysine methylation as potential therapeutic target in pulmonary arterial hypertensionBy Natalia Gambaryan, Chao Meng, Marc Humbert, Ian Adcock and Stephen WortNatalia Gambaryan1Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United KingdomChao Meng1Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United KingdomMarc Humbert2INSERM U999, Centre Chirurgical Marie Lannelongue, Université Paris-Sud 11, Le Plessis-Robinson, FranceIan Adcock1Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United KingdomStephen Wort1Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
- Importin-7 knockdown reduces corticosteroid induced glucocorticoid receptor nuclear localisation and suppression of IL-1β induced CXCL8By Amir Hakim, Peter Barnes, Ian Adcock and Omar UsmaniAmir Hakim1National Heart & Lung Institute, Imperial College, London, United KingdomPeter Barnes1National Heart & Lung Institute, Imperial College, London, United KingdomIan Adcock1National Heart & Lung Institute, Imperial College, London, United KingdomOmar Usmani1National Heart & Lung Institute, Imperial College, London, United Kingdom
- Nitrosative and oxidative stress in virus-induced COPD exacerbationsBy Joseph Footitt, Patrick Mallia, Wanxing Eugene Ho, Chang Cheng, Hong Yong Peh, Maria-Belen Trujillo-Torralbo, Ian Adcock, Peter Barnes, Kazuhiro Ito, Sarah Elkin, Onn Min Kon, Fred Wong and Sebastian JohnstonJoseph Footitt1Airway Disease Infection, Imperial College, London, United KingdomPatrick Mallia1Airway Disease Infection, Imperial College, London, United KingdomWanxing Eugene Ho2Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore, SingaporeChang Cheng2Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore, SingaporeHong Yong Peh2Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore, SingaporeMaria-Belen Trujillo-Torralbo1Airway Disease Infection, Imperial College, London, United KingdomIan Adcock3Airway Disease, National Heart and Lung Institute, Imperial College, London, United KingdomPeter Barnes3Airway Disease, National Heart and Lung Institute, Imperial College, London, United KingdomKazuhiro Ito3Airway Disease, National Heart and Lung Institute, Imperial College, London, United KingdomSarah Elkin1Airway Disease Infection, Imperial College, London, United KingdomOnn Min Kon1Airway Disease Infection, Imperial College, London, United KingdomFred Wong2Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore, SingaporeSebastian Johnston1Airway Disease Infection, Imperial College, London, United Kingdom
- Bromodomain inhibitor JQ1 attenuates TGF-β-suppressed SOD2 expression and reduces proliferation in human primary pulmonary fibroblastsBy Gisela Lindahl, Patricia Leoni, Carmel Stock, Charalambos Michaeloudes, Harpreet Lota, Andrew Nicholson, Toby Maher, Athol Wells, Ian Adcock and Elisabetta RenzoniGisela Lindahl1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United KingdomPatricia Leoni1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United KingdomCarmel Stock1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United KingdomCharalambos Michaeloudes2NHLI, Imperial College London, London, United KingdomHarpreet Lota1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United KingdomAndrew Nicholson3Histopathology, Royal Brompton Hospital, London, United KingdomToby Maher1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United KingdomAthol Wells1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United KingdomIan Adcock2NHLI, Imperial College London, London, United KingdomElisabetta Renzoni1ILDU/NHLI, Royal Brompton Hospital/Imperial College, London, United Kingdom
- Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPDBy Antonino Di Stefano, Gaetano Caramori, Adam Barczyk, Chiara Vicari, Paola Brun, Andrea Zanini, Francesco Cappello, Elvira Garofano, Anna Padovani, Marco Contoli, Andrew Durham, Peter Barnes, Kian Fan Chung, Alberto Papi, Ian Adcock and Bruno BalbiAntonino Di Stefano1Divisione Di Pneumologia e Citoimmunopatologia, Fondazione S. Maugeri, IRCCS, Veruno, Tradate, ItalyGaetano Caramori2Centro Interdipartimentale Per Lo Studio Delle Malattie Infiammatorie Delle Vie Aeree, Università Di Ferrara, Ferrara, ItalyAdam Barczyk3Katedra I Klinika Pneumologii, Universytetu Medycznego W Katowicach, Slaskiego, PolandChiara Vicari1Divisione Di Pneumologia e Citoimmunopatologia, Fondazione S. Maugeri, IRCCS, Veruno, Tradate, ItalyPaola Brun4Department of Biomedical Sciences, Università Di Padova, Padova, ItalyAndrea Zanini1Divisione Di Pneumologia e Citoimmunopatologia, Fondazione S. Maugeri, IRCCS, Veruno, Tradate, ItalyFrancesco Cappello5Dipartimento Di Biomedicina Sperimentale e Neuroscienze Cliniche, Università Di Palermo, Palermo, ItalyElvira Garofano2Centro Interdipartimentale Per Lo Studio Delle Malattie Infiammatorie Delle Vie Aeree, Università Di Ferrara, Ferrara, ItalyAnna Padovani2Centro Interdipartimentale Per Lo Studio Delle Malattie Infiammatorie Delle Vie Aeree, Università Di Ferrara, Ferrara, ItalyMarco Contoli2Centro Interdipartimentale Per Lo Studio Delle Malattie Infiammatorie Delle Vie Aeree, Università Di Ferrara, Ferrara, ItalyAndrew Durham6Airway Disease Section, National Heart and Lung Institute, London, United KingdomPeter Barnes6Airway Disease Section, National Heart and Lung Institute, London, United KingdomKian Fan Chung6Airway Disease Section, National Heart and Lung Institute, London, United KingdomAlberto Papi2Centro Interdipartimentale Per Lo Studio Delle Malattie Infiammatorie Delle Vie Aeree, Università Di Ferrara, Ferrara, ItalyIan Adcock6Airway Disease Section, National Heart and Lung Institute, London, United KingdomBruno Balbi1Divisione Di Pneumologia e Citoimmunopatologia, Fondazione S. Maugeri, IRCCS, Veruno, Tradate, Italy
- Stable isotope labelled amino acid culturing: A novel approach to identify pathways involved in MIF signallingBy Kirsty Russell, Kate Heesom, Simon Hall, Sebastian Johnston, Peter Barnes and Ian AdcockKirsty Russell1Airways Disease, NHLI Imperial College London, London, United KingdomKate Heesom2Proteomics Facility, University of Bristol, Bristol, United KingdomSimon Hall3Respiratory, GlaxoSmithKline, Stevenage, United KingdomSebastian Johnston1Airways Disease, NHLI Imperial College London, London, United KingdomPeter Barnes1Airways Disease, NHLI Imperial College London, London, United KingdomIan Adcock1Airways Disease, NHLI Imperial College London, London, United Kingdom
- The long intergenic non-coding RNA, PVT1, regulates the TGF-β-induced proliferative response in airway smooth muscle cells from severe asthmaticsBy Mark Perry, Phillip Austin, Ian Adcock and Kian Fan ChungMark Perry1Airway Disease, NHLI, Imperial College London, London, United KingdomPhillip Austin1Airway Disease, NHLI, Imperial College London, London, United KingdomIan Adcock1Airway Disease, NHLI, Imperial College London, London, United KingdomKian Fan Chung1Airway Disease, NHLI, Imperial College London, London, United Kingdom
- Effects of cigarette smoke extract on human airway smooth muscle cells in COPDBy Ling Chen, Qi Ge, Gavin Tjin, Hatem Alkhouri, Linghong Deng, Corry-Anke Brandsma, Ian Adcock, Wim Timens, Dirkje Postma, Janette K. Burgess, Judith L. Black and Brian G.G. OliverArticle | Published in 2014 in European Respiratory JournalLing Chen1Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, AustraliaQi Ge2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia3Discipline of Pharmacology, The University of Sydney, Sydney, NSW, AustraliaGavin Tjin2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia4Central Clinical School, The University of Sydney, Sydney, NSW, AustraliaHatem Alkhouri5Respiratory Research Group, Faculty of Pharmacy, The University of Sydney, Sydney, NSW, AustraliaLinghong Deng1Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China6Institute of Biomedical Engineering and Health Science, Changzhou University, Changzhou, Jiangsu, ChinaCorry-Anke Brandsma7Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsIan Adcock8Thoracic Medicine, Imperial College London, National Heart and Lung Institute, London, UKWim Timens7Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsDirkje Postma9Dept of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsJanette K. Burgess2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia3Discipline of Pharmacology, The University of Sydney, Sydney, NSW, Australia4Central Clinical School, The University of Sydney, Sydney, NSW, AustraliaJudith L. Black2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia3Discipline of Pharmacology, The University of Sydney, Sydney, NSW, AustraliaBrian G.G. Oliver2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia10School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, Australia
- Effects of cigarette smoke extract on human airway smooth muscle cells in COPDBy Ling Chen, Qi Ge, Gavin Tjin, Hatem Alkhouri, Linghong Deng, Corry-Anke Brandsma, Ian Adcock, Wim Timens, Dirkje Postma, Janette K. Burgess, Judith L. Black and Brian G.G. OliverLing Chen1Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, AustraliaQi Ge2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia3Discipline of Pharmacology, The University of Sydney, Sydney, NSW, AustraliaGavin Tjin2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia4Central Clinical School, The University of Sydney, Sydney, NSW, AustraliaHatem Alkhouri5Respiratory Research Group, Faculty of Pharmacy, The University of Sydney, Sydney, NSW, AustraliaLinghong Deng1Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China6Institute of Biomedical Engineering and Health Science, Changzhou University, Changzhou, Jiangsu, ChinaCorry-Anke Brandsma7Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsIan Adcock8Thoracic Medicine, Imperial College London, National Heart and Lung Institute, London, UKWim Timens7Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsDirkje Postma9Dept of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsJanette K. Burgess2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia3Discipline of Pharmacology, The University of Sydney, Sydney, NSW, Australia4Central Clinical School, The University of Sydney, Sydney, NSW, AustraliaJudith L. Black2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia3Discipline of Pharmacology, The University of Sydney, Sydney, NSW, AustraliaBrian G.G. Oliver2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia10School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, Australia
- miRNA-145 & SMAD3 expression in patients with COPDBy Lawrence O'Leary, B. Tildy, I. Papazoglou, Ian Adcock, Fan Chung and Mark PerryLawrence O'Leary1NHLI, Airway Disease, Imperial College London, London, United KingdomB. Tildy1NHLI, Airway Disease, Imperial College London, London, United KingdomI. Papazoglou1NHLI, Airway Disease, Imperial College London, London, United KingdomIan Adcock1NHLI, Airway Disease, Imperial College London, London, United KingdomFan Chung1NHLI, Airway Disease, Imperial College London, London, United KingdomMark Perry1NHLI, Airway Disease, Imperial College London, London, United Kingdom
- Mitochondrial membrane potential in the airway and skeletal muscle compartments of smokers with and without COPDBy Gulam Haji, Coen Weigman, Mehul Patel, Diviya Mohan, Paul Kemp, Ian Adcock, Fan Chung and Mike PolkeyGulam Haji1Department of Respiratory Medicine Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom2National Heart and Lung Institute, Imperial College, London, United KingdomCoen Weigman2National Heart and Lung Institute, Imperial College, London, United KingdomMehul Patel1Department of Respiratory Medicine Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom2National Heart and Lung Institute, Imperial College, London, United KingdomDiviya Mohan1Department of Respiratory Medicine Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom2National Heart and Lung Institute, Imperial College, London, United KingdomPaul Kemp2National Heart and Lung Institute, Imperial College, London, United KingdomIan Adcock2National Heart and Lung Institute, Imperial College, London, United KingdomFan Chung1Department of Respiratory Medicine Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom2National Heart and Lung Institute, Imperial College, London, United KingdomMike Polkey1Department of Respiratory Medicine Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom2National Heart and Lung Institute, Imperial College, London, United Kingdom
- Enhanced inflammatory gene expression in bronchial epithelial cells from asthmatic patients: Attenuation by a Brd4 mimicBy Peter Brook, Andrew Durham and Ian AdcockPeter Brook1National Heart and Lung Institute, Imperial College London, London, United KingdomAndrew Durham1National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1National Heart and Lung Institute, Imperial College London, London, United Kingdom
- The role of glycolysis in TGF-β-mediated airway smooth muscle cell proliferationBy Charalambos Michaeloudes, Ian Adcock and Kian Fan ChungCharalambos Michaeloudes1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomKian Fan Chung1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
- The anti-proliferative effect of hydrogen sulfide upon human airway smooth muscle in COPDBy Mark Perry, Alice Tu, Gurpreet Sehra, Ian Adcock and Fan ChungMark Perry1NHLI, Airway Disease, Imperial College London, London, United KingdomAlice Tu1NHLI, Airway Disease, Imperial College London, London, United KingdomGurpreet Sehra1NHLI, Airway Disease, Imperial College London, London, United KingdomIan Adcock1NHLI, Airway Disease, Imperial College London, London, United KingdomFan Chung1NHLI, Airway Disease, Imperial College London, London, United Kingdom
- Gene set variation analysis of mRNA expression in bronchial biopsies from the U-BIOPRED asthma studyBy Stelios Pavlidis, Anthony Rowe, Ian Adcock, Kirsty Russell, Ioannis Pandis, Yi-Ke Guo, Bertrand DMeuldere, Diane Lefaudeux, Charles Auffray, Ratko Djukanovic, Peter Howarth, Fan Chung, Matthew Loza, Navin Rao and Frédéric BaribaudStelios Pavlidis1Research and Development, Janssen, High Wycombe, Buckinghamshire, United KingdomAnthony Rowe1Research and Development, Janssen, High Wycombe, Buckinghamshire, United KingdomIan Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomKirsty Russell2National Heart & Lung Institute, Imperial College London, London, United KingdomIoannis Pandis3Discovery Sciences Group, Imperial College London, London, United KingdomYi-Ke Guo3Discovery Sciences Group, Imperial College London, London, United KingdomBertrand DMeuldere4European Institute for Systems Biology and Medicine (EISBM), CNRS, Lyon, FranceDiane Lefaudeux4European Institute for Systems Biology and Medicine (EISBM), CNRS, Lyon, FranceCharles Auffray4European Institute for Systems Biology and Medicine (EISBM), CNRS, Lyon, FranceRatko Djukanovic5NIHR, Southampton University, Southampton, United KingdomPeter Howarth5NIHR, Southampton University, Southampton, United KingdomFan Chung2National Heart & Lung Institute, Imperial College London, London, United KingdomMatthew Loza6Research and Development, Janssen, Springhouse,Navin Rao6Research and Development, Janssen, Springhouse,Frédéric Baribaud6Research and Development, Janssen, Springhouse,
- The anti-inflammatory effects of sulforaphane are not mediated by the Nrf2 pathwayBy Andrew Durham, Elen Jazrawi, Jo Ann Rhodes, Cara Williams, Ian Kilty, Peter Barnes, K. Fan Chung and Ian AdcockAndrew Durham1National Heart and Lung Institute, Imperial College London, London, United KingdomElen Jazrawi1National Heart and Lung Institute, Imperial College London, London, United KingdomJo Ann Rhodes1National Heart and Lung Institute, Imperial College London, London, United KingdomCara Williams2Pfizer Inc, Pfizer Inc, Cambridge, MA,Ian Kilty2Pfizer Inc, Pfizer Inc, Cambridge, MA,Peter Barnes1National Heart and Lung Institute, Imperial College London, London, United KingdomK. Fan Chung1National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1National Heart and Lung Institute, Imperial College London, London, United Kingdom
- The lipokine, or palmitoleic acid (16:1), is a biomarker of lung function in chronic obstructive pulmonary disease (COPD)By Hiroo Wada, Shin-ichi Hagiwara, Yorihiro Yamamoto, Hajime Goto, Ian Adcock and Hajime TakizawaHiroo Wada1Respiratory Medicine, Kyorin University, Tokyo, JapanShin-ichi Hagiwara2Health Centre, Honda Engineering Co Ltd, Tochigi, JapanYorihiro Yamamoto3School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, JapanHajime Goto1Respiratory Medicine, Kyorin University, Tokyo, JapanIan Adcock4Airway Desaese Section, Imperial College London, London, United KingdomHajime Takizawa1Respiratory Medicine, Kyorin University, Tokyo, Japan
- Oct2 interaction with Brd4 is a key component of immunoglobulin gene expressionBy Andrew Durham, Jung Shim, Jin Lee and Ian AdcockAndrew Durham1National Heart and Lung Institute, Imperial College London, London, United KingdomJung Shim1National Heart and Lung Institute, Imperial College London, London, United KingdomJin Lee1National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Combined analysis of gene expression and clinical data in the severe asthma U-BIOPRED cohortsBy Bertrand De Meulder, Diane Lefaudeux, Mansoor Saqi, Charles Auffray, Ian Adcock, Fan Chung, Jeanette Bigler, Matthew Loza, Navin Rao, Anthony Rowe, Frédéric Baribaud, Graham Roberts, Ana Sousa, Aruna Bansal, Chris Compton, David Myles, Ratko Djukanovic, Dominic Shaw, Ildiko Horvath, Jacek Musial, Julie Corfield, Pascal Chanez, Norbert Krug, Paolo Montuschi, Per Bakke, Peter Sterk, Riccardo Polosa, Scott Wager, Florian Singer, Stephen Fowler, Sven-Erik Dahlen, Thomas Sandström, Timothy Higenbottam, Ulf Nihlén, Urs Frey and Wolfgang SeiboldBertrand De Meulder1EISBM, CNRS, Lyon, Rhone, FranceDiane Lefaudeux1EISBM, CNRS, Lyon, Rhone, FranceMansoor Saqi1EISBM, CNRS, Lyon, Rhone, FranceCharles Auffray1EISBM, CNRS, Lyon, Rhone, FranceIan Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomFan Chung2National Heart & Lung Institute, Imperial College London, London, United KingdomJeanette Bigler3Amgen Inc, Amgen Inc, Seattle,Matthew Loza4Janssen Research and Development, Janssen, Springhouse,Navin Rao4Janssen Research and Development, Janssen, Springhouse,Anthony Rowe4Janssen Research and Development, Janssen, Springhouse,Frédéric Baribaud4Janssen Research and Development, Janssen, Springhouse,Graham Roberts5University Hospital Southampton NHS Foundation Trust, NHS Foundation Trust, Southampton, United KingdomAna Sousa6Discovery Medicine, GlaxoSmithKline, Uxbridge, United KingdomAruna Bansal7Acclarogen, Acclarogen Ltd, Cambridge, United KingdomChris Compton8Respiratory Development, Novartis, Redhill, United KingdomDavid Myles6Discovery Medicine, GlaxoSmithKline, Uxbridge, United KingdomRatko Djukanovic5University Hospital Southampton NHS Foundation Trust, NHS Foundation Trust, Southampton, United KingdomDominic Shaw9Nottingham University Hospital, Nottingham University Hospital, Nottingham, United KingdomIldiko Horvath10Semmelweis University, Semmelweis University, Budapest, HungaryJacek Musial11Allergy and Immunology, Jagiallonian University, Krakow, PolandJulie Corfield12Areteva, Areteva Ltd, Nottingham, United KingdomPascal Chanez13Clinique des Bronches, Allergie et Sommeil, Université de la Méditerranée, Marseille, FranceNorbert Krug14Immunology, Allergology and Clinical Inhalation, Fraunhofer Institute, Hannover, GermanyPaolo Montuschi15Pharmacology, Università Cattolica del Sacro Cuore, Roma, ItalyPer Bakke16Thoracic Medicine, Haukeland University Hospital, Bergen, SwedenPeter Sterk17Pulmonology, Academisch Medisch Centrum, Amsterdam, NetherlandsRiccardo Polosa18Internal Medicine and Clinical Immunology, University of Catania, Catania, ItalyScott Wager19BioSci Consulting, BioSci Consulting, Maasmechelen, BelgiumFlorian Singer20Paediatric Respiratory Medicine, University Hospital, Inselpital, Bern, SwitzerlandStephen Fowler21Respiratory Research Group, University of Manchester, Manchester, United KingdomSven-Erik Dahlen22Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm, SwedenThomas Sandström23Pulmonology, University Hospital, Umea, SwedenTimothy Higenbottam24Corporate Clinical Development, Chiesi Pharmaceutics Ltd, Cheadle, United KingdomUlf Nihlén25AstraZeneca R&D, AstraZeneca, Södertälje, SwedenUrs Frey20Paediatric Respiratory Medicine, University Hospital, Inselpital, Bern, SwitzerlandWolfgang Seibold26Boehringer Ingelheim, Boehringer Ingelheim Corporation, Ingelheim am Rhein, Germany
- ADEPT-derived, U-BIOPRED validated asthma clinical clusters with Th2 and non-Th2 phenotypesBy Matthew Loza, Philip Silkoff, Vedrana Susilic, Anthony Rowe, Ian Adcock, Charles Auffray, Kian Fan Chung, Ratko Djukanovic, Peter Sterk and Frédéric BaribaudMatthew Loza1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Philip Silkoff1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Vedrana Susilic1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Anthony Rowe1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,Ian Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomCharles Auffray3European Institute for Systems Biology and Medicine (EISBM), Centre National de la Recherche Scientifique (CNRS), Campus Charles Mérieux, University of Lyon, Lyon, FranceKian Fan Chung2National Heart & Lung Institute, Imperial College London, London, United KingdomRatko Djukanovic4Academic Unit of Clinical and Experimental Sciences and the NIHR Southampton Respiratory BioMedical Research Unit, Southampton University Hospital, Southampton, United KingdomPeter Sterk5Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, NetherlandsFrédéric Baribaud1Immunology Therapeutic Area, Janssen Research and Development, Spring House, PA,
- Nuclear factor-kappa B inhibition exerts anti-remodelling effects in pulmonary arterial smooth muscle cellsBy Laura Price, Dongmin Shao, Chao Meng, Frederic Perros, David Montani, Peter Dorfmuller, Marc Humbert, Ian Adcock and John WortLaura Price1Pulmonary Hypertension Service, Royal Brompton Hospital, London, United Kingdom2National Heart & Lung Institute, Imperial College London, London, United KingdomDongmin Shao2National Heart & Lung Institute, Imperial College London, London, United KingdomChao Meng2National Heart & Lung Institute, Imperial College London, London, United KingdomFrederic Perros3Service de Pneumologie et Réanimation Respiratoire, Hôpital Bicêtre, 78 rue du Général Leclerc, Le Kremlin-Bicêtre, Paris, France4INSERM U999, Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique, Université Paris-Sud - LabEx LERMIT - DHU Thorax Innovation (TORINO), Centre Chirurgical Marie Lannelongue, Paris, FranceDavid Montani3Service de Pneumologie et Réanimation Respiratoire, Hôpital Bicêtre, 78 rue du Général Leclerc, Le Kremlin-Bicêtre, Paris, France4INSERM U999, Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique, Université Paris-Sud - LabEx LERMIT - DHU Thorax Innovation (TORINO), Centre Chirurgical Marie Lannelongue, Paris, FrancePeter Dorfmuller3Service de Pneumologie et Réanimation Respiratoire, Hôpital Bicêtre, 78 rue du Général Leclerc, Le Kremlin-Bicêtre, Paris, France4INSERM U999, Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique, Université Paris-Sud - LabEx LERMIT - DHU Thorax Innovation (TORINO), Centre Chirurgical Marie Lannelongue, Paris, FranceMarc Humbert3Service de Pneumologie et Réanimation Respiratoire, Hôpital Bicêtre, 78 rue du Général Leclerc, Le Kremlin-Bicêtre, Paris, France4INSERM U999, Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique, Université Paris-Sud - LabEx LERMIT - DHU Thorax Innovation (TORINO), Centre Chirurgical Marie Lannelongue, Paris, FranceIan Adcock2National Heart & Lung Institute, Imperial College London, London, United KingdomJohn Wort1Pulmonary Hypertension Service, Royal Brompton Hospital, London, United Kingdom2National Heart & Lung Institute, Imperial College London, London, United Kingdom
- Mitochondrial reactive oxygen species (ROS) mediate proliferation and cytokine release in airway smooth muscle cells of patients with COPDBy Charalambos Michaeloudes, Coen Wiegman, Paul Kirkham, Kian Fan Chung, Ian Adcock and COPD MAP Consortium WP3Charalambos Michaeloudes1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomCoen Wiegman1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomPaul Kirkham1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomKian Fan Chung1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom1Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Whole transcriptome analysis in peripheral blood from asthmatic and healthy subjects in the U-BIOPRED studyBy Jeannette Bigler, Xuguang Hu, Michael Boedigheimer, Anthony Rowe, Fan Chung, Ratko Djukanovic, Ana Sousa, Julie Corfield, Ian Adcock, Peter Sterk and Andrew WelcherJeannette Bigler1Medical Sciences, Amgen Inc, Seattle, WA,Xuguang Hu1Medical Sciences, Amgen Inc, Seattle, WA,Michael Boedigheimer2Medical Sciences, Amgen Inc, Thousand Oaks, CA,Anthony Rowe3R&D IT - External Innovation, Janssen R&D Ltd, High Wycombe, United KingdomFan Chung4National Heart and Lung Institute, Imperial College, London, United KingdomRatko Djukanovic5Centre for BioMedical Research, University of Southampton, Southampton, United KingdomAna Sousa6Respiratory Therapy Unit, GlaxoSmithKline, Uxbridge, United KingdomJulie Corfield7Areteva, Areteva Ltd, Nottingham, United KingdomIan Adcock4National Heart and Lung Institute, Imperial College, London, United KingdomPeter Sterk8Pulmonology, University of Amsterdam, Amsterdam, NetherlandsAndrew Welcher2Medical Sciences, Amgen Inc, Thousand Oaks, CA,
- Late-breaking abstract: Epigenetic inhibition of proliferation and inflammation in airway epitheliumBy Bianca van Groen, Peter Brook, Ian Adcock and Andrew DurhamBianca van Groen1Pharmacology, Universiteit Utrecht / University of Utrecht, Utrecht, NetherlandsPeter Brook2National Heart and Lung Institute, Imperial College, London, United KingdomIan Adcock2National Heart and Lung Institute, Imperial College, London, United KingdomAndrew Durham2National Heart and Lung Institute, Imperial College, London, United Kingdom
- Microarray analysis of long non-coding RNAs in COPDBy Xin Yao, Hui Bi, Ji Zhou, Mao Huang, Ian Adcock and Peter BarnesXin Yao1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaHui Bi1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaJi Zhou1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaMao Huang1Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaIan Adcock2Airway Disease Section, NHLI, London, United KingdomPeter Barnes2Airway Disease Section, NHLI, London, United Kingdom
- Nuclear IL-33 arguments ST2 receptor expression in pulmonary arterial endothelial cells: Implication in the pathogenesis and progression of pulmonary arterial hypertensionBy Dongmin Shao, Frédéric Perros, Chao Meng, Gaetano Caramori, Marc Humbert, Pai-Chien Chou, Ian Adcock and Stephen WortDongmin Shao1National Heart and Lung Institute, Imperial College London, London, United KingdomFrédéric Perros2INSERM U999, Hôpital Marie Lannelongue, Université Paris Sud, Paris, FranceChao Meng1National Heart and Lung Institute, Imperial College London, London, United KingdomGaetano Caramori3Dipartimento di Medicina Clinica e Sperimentale, Università di Ferrara, Ferrara, ItalyMarc Humbert2INSERM U999, Hôpital Marie Lannelongue, Université Paris Sud, Paris, FrancePai-Chien Chou1National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1National Heart and Lung Institute, Imperial College London, London, United KingdomStephen Wort1National Heart and Lung Institute, Imperial College London, London, United Kingdom
- The effect of JQ1/SGCBD01 upon c-Myc in human airway smooth muscle in asthmaBy Mark Perry, Andrew Durham, Gurpreet Sehra, Ian Adcock and Fan ChungMark Perry1NHLI, Airway Disease, Imperial College London, London, United KingdomAndrew Durham1NHLI, Airway Disease, Imperial College London, London, United KingdomGurpreet Sehra1NHLI, Airway Disease, Imperial College London, London, United KingdomIan Adcock1NHLI, Airway Disease, Imperial College London, London, United KingdomFan Chung1NHLI, Airway Disease, Imperial College London, London, United Kingdom
- Systemic corticosteroid-associated serum analyte profiles in the U-BIOPRED severe asthma cohortBy Matthew Loza, Stelios Pavlidis, Anthony Rowe, Ratko Djukanovic, Peter Sterk, Ian Adcock, Frédéric Baribaud and K. Fan ChungMatthew Loza1Immunology Research, Janssen Research and Development, Spring House, PA United StatesStelios Pavlidis2Immunology Research, Janssen Research and Development, High Wycombe, United KingdomAnthony Rowe3R&D RSQA IT, Janssen Research and Development, High Wycombe, United KingdomRatko Djukanovic4Faculty of Medicine, Southampton University, Southampton, United KingdomPeter Sterk5Respiratory Medicine, University of Amsterdam, Amsterdam, NetherlandsIan Adcock6National Heart & Lung Institute, Imperial College London, London, United KingdomFrédéric Baribaud1Immunology Research, Janssen Research and Development, Spring House, PA United StatesK. Fan Chung6National Heart & Lung Institute, Imperial College London, London, United Kingdom
- Susceptibility to influenza virus infection in asthma biopsies and the effect of topical steroidsBy Ben Nicholas, Sarah Dudley, Kamran Tariq, Peter Howarth, Kerry Lunn, Sandy Pink, Phillip Monk, Ian Adcock, Ratko Djukanovic and The U-BIOPRED Study Group Listed at http://www.europeanlung.org/en/assets/microsites/ubiopred/files/ubiopred_study_groups.pdfBen Nicholas1Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom2Southampton NIHR Biomedical Research Unit and NIHR Wellcome Trust Clinical Research Facility, Southampton General Hospital, Southampton, United KingdomSarah Dudley4Synairgen PLC, Southampton General Hospital, Southampton, United KingdomKamran Tariq1Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom2Southampton NIHR Biomedical Research Unit and NIHR Wellcome Trust Clinical Research Facility, Southampton General Hospital, Southampton, United KingdomPeter Howarth1Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom2Southampton NIHR Biomedical Research Unit and NIHR Wellcome Trust Clinical Research Facility, Southampton General Hospital, Southampton, United KingdomKerry Lunn4Synairgen PLC, Southampton General Hospital, Southampton, United KingdomSandy Pink2Southampton NIHR Biomedical Research Unit and NIHR Wellcome Trust Clinical Research Facility, Southampton General Hospital, Southampton, United KingdomPhillip Monk4Synairgen PLC, Southampton General Hospital, Southampton, United KingdomIan Adcock3National Heart and Lung Institute, Iimperial College, London, United KingdomRatko Djukanovic1Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom2Southampton NIHR Biomedical Research Unit and NIHR Wellcome Trust Clinical Research Facility, Southampton General Hospital, Southampton, United Kingdom1Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom
- The role of hypoxia and the circadian rhythm in sleep apnoeaBy Tessa Jaspers, Mary Morrell, Anita Simonds, Ian Adcock and Andrew DurhamTessa JaspersNational Heart & Lung Institute, Imperial College London, London, United KingdomMary MorrellNational Heart & Lung Institute, Imperial College London, London, United KingdomAnita SimondsNational Heart & Lung Institute, Imperial College London, London, United KingdomIan AdcockNational Heart & Lung Institute, Imperial College London, London, United KingdomAndrew DurhamNational Heart & Lung Institute, Imperial College London, London, United Kingdom
- Characteristics of asthma in U-BIOPRED severe and non-severe cohorts with distinct biomarker profilesBy Edward Ingenito, Jeanette Bigler, Dirk Smith, Anthony Rowe, Fan Chung, Ratko Djukanovic, Ana Sousa, Ian Adcock, Peter Sterk and Ajay NirulaEdward Ingenito1Clinical Development, Amgen Inc, Cambridge, MA United StatesJeanette Bigler2Medical Sciences, Amgen Inc, Seattle, United StatesDirk Smith3Inflammation Research, Amgen Inc, Seattle, United StatesAnthony Rowe4Research and Development, Janssen, High Wycombe, United KingdomFan Chung5Pulmonary Medicine, Imperial College, London, United KingdomRatko Djukanovic6Pulmonary Medicine, Southampton University, Soithampton, United KingdomAna Sousa7Research and Development, GlaxoSmithKline, Stockley Park, United KingdomIan Adcock5Pulmonary Medicine, Imperial College, London, United KingdomPeter Sterk8Pulmonary Medicine, University of Amsterdam, Amsterdam, NetherlandsAjay Nirula1Clinical Development, Amgen Inc, Cambridge, MA United States
- In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588By Coen Wiegman, Ian Adcock, Alan Rothaul, Mark Main and Frazer MorganCoen Wiegman1Airway Disease, National Heart & Lung Institute, Imperial College London, London, United KingdomIan Adcock1Airway Disease, National Heart & Lung Institute, Imperial College London, London, United KingdomAlan Rothaul2Vectura, Vectura Limited, Chippenham, United KingdomMark Main2Vectura, Vectura Limited, Chippenham, United KingdomFrazer Morgan2Vectura, Vectura Limited, Chippenham, United Kingdom
- Characterisation of a novel 3D model of the airwaysBy Tankut G. Guney, Henry Danahay, Andrew L. Durham, Christos Rossios, Fan Chung, Mark Dowling and Ian AdcockTankut G. Guney1Airway Disease, Imperial College London, London, United KingdomHenry Danahay3Biochemistry, University of Sussex, Brighton, United KingdomAndrew L. Durham1Airway Disease, Imperial College London, London, United KingdomChristos Rossios1Airway Disease, Imperial College London, London, United KingdomFan Chung1Airway Disease, Imperial College London, London, United KingdomMark Dowling2Respiratory Diseases, Novartis Institutes for Biomedical Research, Boston, United StatesIan Adcock1Airway Disease, Imperial College London, London, United Kingdom
- Investigating mitochondrial dysfunction in asthmaBy Rebekah Ashmore, Andrew Durham, Charalambos Michaeloudes, Christos Rossios and Ian AdcockRebekah AshmoreAirways Disease, Imperial College London, London, United KingdomAndrew DurhamAirways Disease, Imperial College London, London, United KingdomCharalambos MichaeloudesAirways Disease, Imperial College London, London, United KingdomChristos RossiosAirways Disease, Imperial College London, London, United KingdomIan AdcockAirways Disease, Imperial College London, London, United Kingdom
- Organic components of diesel exhaust particles (DEP) activate airway sensory nerves via transient receptor potential ankrin-1 (TRPA1) ion channelsBy Ryan Robinson, Michael Wortley, Eric Dubuis, Shu Chen, Sheng Hu, Sara Bonvini, Sarah Maher, John Adcock, Ian Mudway, Alexandra Porter, Terry Tetley, Mark Birrell and Maria BelvisiRyan Robinson1National Heart and Lung Institute, Imperial College London, London, United KingdomMichael Wortley1National Heart and Lung Institute, Imperial College London, London, United KingdomEric Dubuis1National Heart and Lung Institute, Imperial College London, London, United KingdomShu Chen2Department of Materials, Imperial College London, London, United KingdomSheng Hu3Department of Chemistry, Imperial College London, London, United KingdomSara Bonvini1National Heart and Lung Institute, Imperial College London, London, United KingdomSarah Maher1National Heart and Lung Institute, Imperial College London, London, United KingdomJohn Adcock1National Heart and Lung Institute, Imperial College London, London, United KingdomIan Mudway4Environmental Research Group, Kings College London, London, United KingdomAlexandra Porter2Department of Materials, Imperial College London, London, United KingdomTerry Tetley1National Heart and Lung Institute, Imperial College London, London, United KingdomMark Birrell1National Heart and Lung Institute, Imperial College London, London, United KingdomMaria Belvisi1National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Effect of epigenetic probes on IL-1B and polyIC treated normal human epithelial cellsBy Peter Brook, Andrew Durham and Ian AdcockPeter BrookAirways Disease, National Heart and Lung Institute, London, United KingdomAndrew DurhamAirways Disease, National Heart and Lung Institute, London, United KingdomIan AdcockAirways Disease, National Heart and Lung Institute, London, United Kingdom
- Effects of hydrogen sulfide on ozone-induced features of chronic obstructive pulmonary diseaseBy Feng Li, Pengyu Zhang, Min Zhang, Li Liang, Xiaoyuan Sun, Aihua Bao, Min Li, Yueqin Tang, Jicheng Gong, Jim (Junfeng) Zhang, Ian Adcock, Kian Fan Chung and Xin ZhouFeng Li1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaPengyu Zhang1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaMin Zhang1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaLi Liang3Dept of Respiratory Medicine, Shanghai Third People Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaXiaoyuan Sun1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaAihua Bao1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaMin Li1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaYueqin Tang1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, ChinaJicheng Gong4Division of Environmental Sciences & Policy, Duke University, Durham, United StatesJim (Junfeng) Zhang4Division of Environmental Sciences & Policy, Duke University, Durham, United StatesIan Adcock5Airway Diseases Section, National Heart and Lung Institute, Imperial College London, London, United KingdomKian Fan Chung5Airway Diseases Section, National Heart and Lung Institute, Imperial College London, London, United KingdomXin Zhou1Dept of Respiratory Medicine, Shanghai First People Hospital, Shanghai Jiaotong University, Shanghai, China
- Th2 subsetting of U-BIOPRED asthma subjects based on airway transciptomic profilesBy Stelios Pavlidis, Matthew Loza, Frédéric Baribaud, Chih-Hsi Kuo, Anthony Rowe, Rene Lutter, Uruj Hoda, Christos Rossios, Ana Sousa, Julie Corfield, Ian Adcock, Ratko Djukanovic, Peter Sterk and Fan ChungStelios Pavlidis1Research and Development, Janssen, High Wycombe, Buckinghamshire United KingdomMatthew Loza2Immunology Biomarkers, Janssen, Ambler, PA United StatesFrédéric Baribaud2Immunology Biomarkers, Janssen, Ambler, PA United StatesChih-Hsi Kuo3National Heart & Lung Institute, Imperial College London, London, United KingdomAnthony Rowe1Research and Development, Janssen, High Wycombe, Buckinghamshire United KingdomRene Lutter4Academic Medical Center, University of Amsterdam, Amsterdam, NetherlandsUruj Hoda3National Heart & Lung Institute, Imperial College London, London, United KingdomChristos Rossios3National Heart & Lung Institute, Imperial College London, London, United KingdomAna Sousa5Director of Discovery, GlaxoSmithKline, London, United KingdomJulie Corfield6Biobanking, R&D, Areteva, Nottingham, United KingdomIan Adcock3National Heart & Lung Institute, Imperial College London, London, United KingdomRatko Djukanovic7Southampton Centre for Biomedical Research, University of Southampton School of Medicine, Southampton, United KingdomPeter Sterk4Academic Medical Center, University of Amsterdam, Amsterdam, NetherlandsFan Chung3National Heart & Lung Institute, Imperial College London, London, United Kingdom
- Physiology of severe vs. mild-moderate U-BIOPRED cohorts interpreted using a computational modelBy Edward Ingenito, Jeanette Bigler, Dirk Smith, Ian Adcock, Anthony Rowe, Fan Chung, Ratko Djukanovic, Ana Sousa, Peter Sterk and Ajay NirulaEdward Ingenito1Clinical Development, Amgen Inc, Cambridge, MA United StatesJeanette Bigler2Medical Sciences, Amgen Inc, Seattle, WA United StatesDirk Smith3Inflammation Research, Amgen Inc, Seattle, WA United StatesIan Adcock4Southamptom University, Imperial College, London, United KingdomAnthony Rowe5Research and Development, Janssen, High Wycombe, United KingdomFan Chung4Southamptom University, Imperial College, London, United KingdomRatko Djukanovic6Research, Southampton University, Southampton, United KingdomAna Sousa7Research, GlaxoSmithKline, Stockley Park, United KingdomPeter Sterk8Pulmonary Medicine, University of Amsterdam, Amsterdam, NetherlandsAjay Nirula1Clinical Development, Amgen Inc, Cambridge, MA United States
- Mitochondrial function in three different types of airway epithelial cellsBy Weerawon Thangboonjit, Peter Barnes, Andrew Durham and Ian AdcockWeerawon Thangboonjit1National Heart and Lung Institute, Imperial College London, London, United Kingdom2Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandPeter Barnes1National Heart and Lung Institute, Imperial College London, London, United KingdomAndrew Durham1National Heart and Lung Institute, Imperial College London, London, United KingdomIan Adcock1National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Mapping a mouse model of severe asthma to human asthma using gene set variation analysisBy Kirsty Russell, Stelios Pavlidis, Coen Wiegman, Jeannette Bigler, Navin Rao, Kian Fan Chung and Ian AdcockKirsty Russell1NHLI, Imperial College London, London, United KingdomStelios Pavlidis2R&D, Janssen R&D, High Wycombe, United KingdomCoen Wiegman1NHLI, Imperial College London, London, United KingdomJeannette Bigler3Molecular Sciences, Amgen, Seattle, WA United StatesNavin Rao4R&D, Janssen Pharmaceutical R&D, L.L.C., La Jolla, CA United StatesKian Fan Chung1NHLI, Imperial College London, London, United KingdomIan Adcock1NHLI, Imperial College London, London, United Kingdom
- Effects of dexamethasone and anti-inflammatory drugs on inflammatory cytokines from bronchial epithelial cells of COPD patientsBy Ibrahim Koc, Bulent Gogebakan, Recep Bayraktar, Demet Tasdemir, Ufkun Ozdemir, Ian Adcock and Hasan BayramIbrahim Koc1Pulmonary Medicine, Viransehir State Hospital, Sanliurfa, TurkeyBulent Gogebakan3Medical Biology, Mustafa Kemal University, Hatay, TurkeyRecep Bayraktar2Respiratory Research Laboratory, Department of Chest Diseases, University of Gaziantep, TR, Gaziantep, TurkeyDemet Tasdemir2Respiratory Research Laboratory, Department of Chest Diseases, University of Gaziantep, TR, Gaziantep, TurkeyUfkun Ozdemir2Respiratory Research Laboratory, Department of Chest Diseases, University of Gaziantep, TR, Gaziantep, TurkeyIan Adcock2Respiratory Research Laboratory, Department of Chest Diseases, University of Gaziantep, TR, Gaziantep, TurkeyHasan Bayram2Respiratory Research Laboratory, Department of Chest Diseases, University of Gaziantep, TR, Gaziantep, Turkey
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